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Hoang P, Dalton HR, Jewell DP. Human colonic intra-epithelial lymphocytes are suppressor cells. Clin Exp Immunol. 1991;85(3):498-503doi: 10.1111/j.1365-2249.1991.tb05756.x.
Hoang, P., Dalton, H. R., & Jewell, D. P. (1991). Human colonic intra-epithelial lymphocytes are suppressor cells. Clinical and experimental immunology, 85(3), 498-503. https://doi.org/10.1111/j.1365-2249.1991.tb05756.x
Hoang, P, et al. "Human colonic intra-epithelial lymphocytes are suppressor cells." Clinical and experimental immunology vol. 85,3 (1991): 498-503. doi: https://doi.org/10.1111/j.1365-2249.1991.tb05756.x
Hoang P, Dalton HR, Jewell DP. Human colonic intra-epithelial lymphocytes are suppressor cells. Clin Exp Immunol. 1991 Sep;85(3):498-503. doi: 10.1111/j.1365-2249.1991.tb05756.x. PMID: 1832599; PMCID: PMC1535625.
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Clin Exp Immunol. 1991 Sep;85(3):498-503. doi: 10.1111/j.1365-2249.1991.tb05756.x.

Human colonic intra-epithelial lymphocytes are suppressor cells.

Clinical and experimental immunology

P Hoang, H R Dalton, D P Jewell

Affiliations

  1. Gastroenterology Unit, Radcliffe Infirmary, Oxford, England, UK.

PMID: 1832599 PMCID: PMC1535625 DOI: 10.1111/j.1365-2249.1991.tb05756.x
Free PMC Article

Abstract

Human colonic intra-epithelial lymphocytes (IEL) suppress the proliferation of autologous lamina propria lymphocytes, but not autologous peripheral blood mononuclear cells, when stimulated with phytohaemagglutinin. This suppressor function is mediated by a CD8-dependent soluble factor and is not related to the expression of the gamma delta T cell receptor. These findings may be relevant to the induction of mucosal tolerance. However, there is no defect in suppressor activity of colonic IEL in inflammatory bowel disease.

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