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Palmer BR, Pilbrow AP, Frampton CM, et al. Plasma aldosterone levels during hospitalization are predictive of survival post-myocardial infarction. Eur Heart J. 2008;29(20):2489-96doi: 10.1093/eurheartj/ehn383.
Palmer, B. R., Pilbrow, A. P., Frampton, C. M., Yandle, T. G., Skelton, L., Nicholls, M. G., & Richards, A. M. (2008). Plasma aldosterone levels during hospitalization are predictive of survival post-myocardial infarction. European heart journal, 29(20), 2489-96. https://doi.org/10.1093/eurheartj/ehn383
Palmer, Barry R, et al. "Plasma aldosterone levels during hospitalization are predictive of survival post-myocardial infarction." European heart journal vol. 29,20 (2008): 2489-96. doi: https://doi.org/10.1093/eurheartj/ehn383
Palmer BR, Pilbrow AP, Frampton CM, Yandle TG, Skelton L, Nicholls MG, Richards AM. Plasma aldosterone levels during hospitalization are predictive of survival post-myocardial infarction. Eur Heart J. 2008 Oct;29(20):2489-96. doi: 10.1093/eurheartj/ehn383. Epub 2008 Aug 28. PMID: 18757359.
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Eur Heart J. 2008 Oct;29(20):2489-96. doi: 10.1093/eurheartj/ehn383. Epub 2008 Aug 28.

Plasma aldosterone levels during hospitalization are predictive of survival post-myocardial infarction.

European heart journal

Barry R Palmer, Anna P Pilbrow, Christopher M Frampton, Tim G Yandle, Lorraine Skelton, M Gary Nicholls, A Mark Richards

Affiliations

  1. Department of Medicine, Christchurch Cardioendocrine Research Group, Christchurch School of Medicine and Health Sciences, University of Otago, Christchurch 8140, New Zealand.

PMID: 18757359 DOI: 10.1093/eurheartj/ehn383

Abstract

AIMS: Plasma aldosterone levels have been shown to be associated with adverse clinical outcomes after ST-elevation myocardial infarction (STEMI). We investigated whether aldosterone levels in patients presenting with STEMI or non-STEMI, are predictive of mortality during prolonged follow-up.

METHODS AND RESULTS: Aldosterone levels were assayed in plasma taken from 583 patients within 24-96 h following acute myocardial infarction (MI). The median plasma aldosterone level was 108 pmol/L and all values were below the upper limit of the normal range (800 pmol/L) except for five patients (0.9%). Aldosterone tertile was significantly associated with increasing plasma levels of NTproBNP (N-terminal pro-B-type natriuretic peptide), BNP (B-type natriuretic peptide), epinephrine, and endothelin-1 (P or=25.3% mortality, P >or= 0.026).

CONCLUSION: Plasma aldosterone levels post-MI are independent predictors of survival and hospitalization for heart failure over a 5-year-follow-up period.

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