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Resstel LB, de Andrade CR, Haddad R, et al. Hyperhomocysteinaemia-induced cardiovascular changes in rats. Clin Exp Pharmacol Physiol. 2008;35(8):949-56doi: 10.1111/j.1440-1681.2008.04940.x.
Resstel, L. B., de Andrade, C. R., Haddad, R., Eberlin, M. N., de Oliveira, A. M., & Corrêa, F. M. (2008). Hyperhomocysteinaemia-induced cardiovascular changes in rats. Clinical and experimental pharmacology & physiology, 35(8), 949-56. https://doi.org/10.1111/j.1440-1681.2008.04940.x
Resstel, Leonardo B M, et al. "Hyperhomocysteinaemia-induced cardiovascular changes in rats." Clinical and experimental pharmacology & physiology vol. 35,8 (2008): 949-56. doi: https://doi.org/10.1111/j.1440-1681.2008.04940.x
Resstel LB, de Andrade CR, Haddad R, Eberlin MN, de Oliveira AM, Corrêa FM. Hyperhomocysteinaemia-induced cardiovascular changes in rats. Clin Exp Pharmacol Physiol. 2008 Aug;35(8):949-56. doi: 10.1111/j.1440-1681.2008.04940.x. PMID: 18430058.
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Clin Exp Pharmacol Physiol. 2008 Aug;35(8):949-56. doi: 10.1111/j.1440-1681.2008.04940.x.

Hyperhomocysteinaemia-induced cardiovascular changes in rats.

Clinical and experimental pharmacology & physiology

Leonardo B M Resstel, Claudia R de Andrade, Renato Haddad, Marcos N Eberlin, Ana M de Oliveira, Fernando M A Corrêa

Affiliations

  1. Department of Pharmacology, School of Medicine, University of São Paulo, Ribeiraão Preto, Brazil.

PMID: 18430058 DOI: 10.1111/j.1440-1681.2008.04940.x

Abstract

(1) Increased plasma homocysteine content and increased blood pressure are independently associated with higher cardiovascular risks. The present study was designed to determine the effects of hyperhomocysteinaemia (HHcys) on the activity of the cardiovascular system in rats. (2) Using male Wistar rats, the effect of moderate HHcys, induced by treating rats with dl-homocysteine thiolactone (DL-HT; 1 g/kg per day) for 15 days, on arterial blood pressure, heart rate, baroreflex and vascular reactivity was determined. (3) Hyperhomocysteinaemia was observed after 15 days of treatment. Baseline arterial blood pressure and heart rate values of HHcys animals were significantly increased after 15 days of treatment. Plasma homocysteine and cardiovascular parameters returned to control values after termination of treatment. Baroreflex gain was significantly enhanced in HHcys rats. The pressor effect of an i.v. infusion of phenylephrine (50 mg/kg per mL) was decreased in HHcys rats and returned to control values after washout of DL-HT. Hypotensive responses to i.v. infusions of sodium nitroprusside (70 mg/kg per mL) or acetylcholine (10 mg/kg per mL) were increased in HHcys animals and returned to control values after washout of DL-HT. The increase in resting arterial blood pressure associated with the moderate HHcys was reversed by treatment with the b1-adrenoceptor antagonist atenolol, suggesting that HHcys-related hypertension is related to increase in cardiac sympathetic activity. (4) The present study showed significantly increased arterial blood pressure, heart rate and baroreflex activity in the early phase of moderate HHcys. In addition, HHcys was associated with alterations of vascular responsiveness to pressor and depressor agents, as well as increased cardiac sympathetic activity. The fact that cardiovascular changes observed in HHcys were reversed after DL-HT washout indicate that moderate HHcys evokes cardiovascular changes.

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