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Soylu A, Taskale MG, Ciltas A, et al. Intrahepatic cholestasis in subclinical and overt hyperthyroidism: two case reports. J Med Case Rep. 2008;2:116doi: 10.1186/1752-1947-2-116.
Soylu, A., Taskale, M. G., Ciltas, A., Kalayci, M., & Kumbasar, A. B. (2008). Intrahepatic cholestasis in subclinical and overt hyperthyroidism: two case reports. Journal of medical case reports, 2116. https://doi.org/10.1186/1752-1947-2-116
Soylu, Aliye, et al. "Intrahepatic cholestasis in subclinical and overt hyperthyroidism: two case reports." Journal of medical case reports vol. 2 (2008): 116. doi: https://doi.org/10.1186/1752-1947-2-116
Soylu A, Taskale MG, Ciltas A, Kalayci M, Kumbasar AB. Intrahepatic cholestasis in subclinical and overt hyperthyroidism: two case reports. J Med Case Rep. 2008 Apr 21;2:116. doi: 10.1186/1752-1947-2-116. PMID: 18426598; PMCID: PMC2365967.
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J Med Case Rep. 2008 Apr 21;2:116. doi: 10.1186/1752-1947-2-116.

Intrahepatic cholestasis in subclinical and overt hyperthyroidism: two case reports.

Journal of medical case reports

Aliye Soylu, Mustafa Gurkan Taskale, Aydin Ciltas, Mustafa Kalayci, A Baki Kumbasar

Affiliations

  1. Department of Gastroenterology, Dr Sadi Konuk Research Hospital, Istanbul, Turkey. [email protected]

PMID: 18426598 PMCID: PMC2365967 DOI: 10.1186/1752-1947-2-116

Abstract

INTRODUCTION: Non-specific abnormalities in liver function tests might accompany the clinical course of hyperthyroidism. Hyperthyroidism can cause the elevation of hepatic enzymes and bilirubin. Jaundice is rare in overt hyperthyroidism, especially in subclinical hyperthyroidism. On the other hand, the use of anti-thyroid drugs has rarely been associated with toxic hepatitis and cholestatic jaundice.

CASE PRESENTATION: Here we present two cases of cholestasis that accompanied two distinct forms of clinical hyperthyroidism. The first patient had a clinical presentation of severe cholestasis in the absence of congestive failure related to hyperthyroidism. The second case had developed intrahepatic cholestasis in the presence of subclinical hyperthyroidism, and improved with rifampicin treatment.

CONCLUSION: Hyperthyroidism should be a consideration in non-specific liver dysfunction.

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