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Rademaker M, Wallace M, Cunliffe W, et al. Isotretinoin treatment alters steroid metabolism in women with acne. Br J Dermatol. 1991;124(4):361-4doi: 10.1111/j.1365-2133.1991.tb00598.x.
Rademaker, M., Wallace, M., Cunliffe, W., & Simpson, N. B. (1991). Isotretinoin treatment alters steroid metabolism in women with acne. The British journal of dermatology, 124(4), 361-4. https://doi.org/10.1111/j.1365-2133.1991.tb00598.x
Rademaker, M, et al. "Isotretinoin treatment alters steroid metabolism in women with acne." The British journal of dermatology vol. 124,4 (1991): 361-4. doi: https://doi.org/10.1111/j.1365-2133.1991.tb00598.x
Rademaker M, Wallace M, Cunliffe W, Simpson NB. Isotretinoin treatment alters steroid metabolism in women with acne. Br J Dermatol. 1991 Apr;124(4):361-4. doi: 10.1111/j.1365-2133.1991.tb00598.x. PMID: 1827343.
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Br J Dermatol. 1991 Apr;124(4):361-4. doi: 10.1111/j.1365-2133.1991.tb00598.x.

Isotretinoin treatment alters steroid metabolism in women with acne.

The British journal of dermatology

M Rademaker, M Wallace, W Cunliffe, N B Simpson

Affiliations

  1. Department of Dermatology, Glasgow Royal Infirmary, U.K.

PMID: 1827343 DOI: 10.1111/j.1365-2133.1991.tb00598.x

Abstract

The effect of isotretinoin (Roaccutane) on serum steroids and urinary steroid metabolites was investigated in seven female patients receiving the drug for treatment of severe acne over a 16-week period. Serum concentrations of dehydroepiandrosterone sulphate (DHAS), androstenedione (A2), and free androgen index (FAI) were not significantly altered. There was a significant fall in testosterone during treatment and a significant reduction in the 24 h urinary excretion of androsterone, tetrahydrocortisone (THE) and tetrahydrocortisol (THF) from week 8 onwards and for aetiocholanolone and allo-THF from week 12 (P less than 0.05). Although pretreatment levels of urinary steroid metabolites were not abnormal, the ratios of the 5 alpha/5 beta metabolites (androsterone:aetiocholanolone and allo-THF:THF) were at the upper limit of the reference range and were lowered after treatment, suggesting that 5 alpha-reductase activity is sensitive to isotretinoin.

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