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Alves MJ, Rondon MU, Santos AC, et al. Sympathetic nerve activity restrains reflex vasodilatation in heart failure. Clin Auton Res. 2007;17(6):364-9doi: 10.1007/s10286-007-0448-6.
Alves, M. J., Rondon, M. U., Santos, A. C., Dias, R. G., Barretto, A. C., Krieger, E. M., Middlekauff, H. R., & Negrão, C. E. (2007). Sympathetic nerve activity restrains reflex vasodilatation in heart failure. Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 17(6), 364-9. https://doi.org/10.1007/s10286-007-0448-6
Alves, Maria Janieire N N, et al. "Sympathetic nerve activity restrains reflex vasodilatation in heart failure." Clinical autonomic research : official journal of the Clinical Autonomic Research Society vol. 17,6 (2007): 364-9. doi: https://doi.org/10.1007/s10286-007-0448-6
Alves MJ, Rondon MU, Santos AC, Dias RG, Barretto AC, Krieger EM, Middlekauff HR, Negrão CE. Sympathetic nerve activity restrains reflex vasodilatation in heart failure. Clin Auton Res. 2007 Dec;17(6):364-9. doi: 10.1007/s10286-007-0448-6. Epub 2007 Nov 27. PMID: 18043866.
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Clin Auton Res. 2007 Dec;17(6):364-9. doi: 10.1007/s10286-007-0448-6. Epub 2007 Nov 27.

Sympathetic nerve activity restrains reflex vasodilatation in heart failure.

Clinical autonomic research : official journal of the Clinical Autonomic Research Society

Maria Janieire N N Alves, Maria Urbana P B Rondon, Amilton C Santos, Rodrigo G Dias, Antonio Carlos P Barretto, Eduardo M Krieger, Holly R Middlekauff, Carlos Eduardo Negrão

Affiliations

  1. Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil.

PMID: 18043866 DOI: 10.1007/s10286-007-0448-6

Abstract

BACKGROUND: Blunted reflex muscle vasodilatory response during exercise in heart failure (HF) patients may be secondary to augmented vasoconstriction. We tested the hypothesis that the exaggerated sympathetic nerve activity restrains the reflex muscle vasodilatation during exercise in HF patients.

METHODS: We studied the reflex vasodilatory response (plethysmography) during 3 min static handgrip exercise at 30% maximal voluntary contraction in 10 advanced HF patients (45 +/- 3 year, NYHA Functional Class III/IV) and 10 age-matched normal controls (NC, 40 +/- 3 year, P = 0.23) during intra-arterial infusion of: (1) saline control; and (2) alpha-adrenergic blocker (phentolamine).

RESULTS: Baseline forearm vascular conductance (FVC) was lower in HF patients than in NC (2.07 +/- 0.2 vs. 4.26 +/- 0.6 units, respectively; P = 0.002). FVC responses during exercise increased significantly in NC, but not in HF patients (delta changes: 1.05 +/- 0.4 vs. 0.05 +/- 0.2 units, respectively). Phentolamine significantly increased resting FVC in HF patients (from 2.07 +/- 0.2 to 5.74 +/- 0.7 units, P = 0.00004) and restored reflex vasodilatory responses during exercise (delta changes: from 0.05 +/- 0.2 to 1.82 +/- 0.9 units) eliminating the difference in FVC between both groups.

CONCLUSIONS: The blunted reflex muscle vasodilatory response during exercise in advanced HF patients is, at least in part, due to the increase in sympathetic nerve activity.

References

  1. Am J Physiol Heart Circ Physiol. 2005 Aug;289(2):H593-9 - PubMed
  2. Am J Physiol Heart Circ Physiol. 2001 Mar;280(3):H1286-92 - PubMed
  3. Circulation. 1997 Sep 16;96(6):1835-42 - PubMed
  4. J Clin Invest. 1968 Apr;47(4):960-70 - PubMed
  5. Clin Sci (Lond). 2000 Jul;99(1):57-63 - PubMed
  6. J Auton Nerv Syst. 1982 Nov;6(3):287-91 - PubMed
  7. Clin Auton Res. 2007 Feb;17(1):33-8 - PubMed
  8. Circulation. 1993 Jul;88(1):55-61 - PubMed
  9. Clin Sci (Lond). 1990 Jan;78(1):89-93 - PubMed
  10. Ann Intern Med. 2000 Nov 7;133(9):714-25 - PubMed
  11. Am J Physiol Heart Circ Physiol. 2000 Jan;278(1):H168-74 - PubMed
  12. J Am Coll Cardiol. 1996 Sep;28(3):585-90 - PubMed
  13. Circulation. 1994 Aug;90(2):658-68 - PubMed
  14. J Physiol. 1997 Jan 15;498 ( Pt 2):531-40 - PubMed
  15. Circulation. 1991 Oct;84(4):1589-96 - PubMed
  16. J Physiol. 1995 Oct 1;488 ( Pt 1):259-65 - PubMed

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