Display options
Cite
Chen ZX, Xue YQ, Zhang R, et al. A clinical and experimental study on all-trans retinoic acid-treated acute promyelocytic leukemia patients. Blood. 1991;78(6):1413-9
Chen, Z. X., Xue, Y. Q., Zhang, R., Tao, R. F., Xia, X. M., Li, C., Wang, W., Zu, W. Y., Yao, X. Z., & Ling, B. J. (1991). A clinical and experimental study on all-trans retinoic acid-treated acute promyelocytic leukemia patients. Blood, 78(6), 1413-9.
Chen, Z X, et al. "A clinical and experimental study on all-trans retinoic acid-treated acute promyelocytic leukemia patients." Blood vol. 78,6 (1991): 1413-9.
Chen ZX, Xue YQ, Zhang R, Tao RF, Xia XM, Li C, Wang W, Zu WY, Yao XZ, Ling BJ. A clinical and experimental study on all-trans retinoic acid-treated acute promyelocytic leukemia patients. Blood. 1991 Sep 15;78(6):1413-9. PMID: 1884013.
Copy Download .nbib Format: NLM
Share it on

Blood. 1991 Sep 15;78(6):1413-9.

A clinical and experimental study on all-trans retinoic acid-treated acute promyelocytic leukemia patients.

Blood

Z X Chen, Y Q Xue, R Zhang, R F Tao, X M Xia, C Li, W Wang, W Y Zu, X Z Yao, B J Ling

Affiliations

  1. Hematology Department, First Affiliated Hospital, Suzhou Medical College, Jiangsu, People's Republic of China.

PMID: 1884013

Abstract

Fifty patients with acute promyelocytic leukemia (APL) have been treated with all-trans retinoic acid (RA). In vitro induced differentiation of primarily cultured bone marrow cells from the patients, colony-forming unit granulocyte-macrophage (CFU-GM) and L-CFU colony-forming assays, and karyotype analysis were performed over the treatment course. The very high bone marrow complete remission (CR) rate (94%) suggested that all-trans RA was superior to conventional chemotherapeutic regimens for the treatment of APL. The leukemic clone was reduced by RA-induced terminal differentiation and loss of proliferation capacity of leukemic cells. Relapse after CR in about 40% of patients was the major reason for the failure of the RA treatment. Patients who relapsed after a chemotherapy-maintained CR could be effectively reinduced to second CR by RA. However, if relapse occurred after a CR maintained by both RA and chemotherapy, the sensitivity of newly emerged leukemic clones to RA was greatly reduced. Therefore, it is suggested that RA should be replaced by conventional chemotherapy as soon as CR is achieved. Laboratory studies proved valuable in selecting cases for RA therapy and in predicting therapeutic effects and prognosis.

Cited by

Wang J, Wei L, Han Y, Qin D, Yang Q, Ju X.
Open Med (Wars). 2015 Aug 03;10(1):329-334. doi: 10.1515/med-2015-0048. eCollection 2015.
PMID: 28352714

Substances

MeSH terms

Publication Types

LinkOut - more resources