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Mohr W, Lehmann H. Osteoarthrosis of the ankle joints in old rats. Z Rheumatol. 1992;51(1):35-40
Mohr, W., & Lehmann, H. (1992). Osteoarthrosis of the ankle joints in old rats. Zeitschrift fur Rheumatologie, 51(1), 35-40.
Mohr, W, and Lehmann, H. "Osteoarthrosis of the ankle joints in old rats." Zeitschrift fur Rheumatologie vol. 51,1 (1992): 35-40.
Mohr W, Lehmann H. Osteoarthrosis of the ankle joints in old rats. Z Rheumatol. 1992 Jan-Feb;51(1):35-40. PMID: 1574936.
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Z Rheumatol. 1992 Jan-Feb;51(1):35-40.

Osteoarthrosis of the ankle joints in old rats.

Zeitschrift fur Rheumatologie

W Mohr, H Lehmann

Affiliations

  1. Abteilung Pathologie, Universität Ulm.

PMID: 1574936

Abstract

The paper describes results of histological investigations on 26-month-old rats with osteoarthrosis of the ankle joints. From the morphological appearance a sequence of alterations from focal chondrocytic necroses, fibrillation to partial or total cartilage loss occurred. The reported changes were often present in opposing cartilage contact zones. A synovitis seems not to be involved in this cartilage destructive process. It is assumed that this spontaneously occurring osteoarthrosis can be used as a model to study the mechanisms leading to cartilage destruction. The model may further be useful to elucidate protective or detrimental effects of therapeutic substances.

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