Display options
Cite
Straub SV, Nelson MT. Astrocytic calcium signaling: the information currency coupling neuronal activity to the cerebral microcirculation. Trends Cardiovasc Med. 2007;17(6):183-90doi: 10.1016/j.tcm.2007.05.001.
Straub, S. V., & Nelson, M. T. (2007). Astrocytic calcium signaling: the information currency coupling neuronal activity to the cerebral microcirculation. Trends in cardiovascular medicine, 17(6), 183-90. https://doi.org/10.1016/j.tcm.2007.05.001
Straub, Stephen V, and Nelson, Mark T. "Astrocytic calcium signaling: the information currency coupling neuronal activity to the cerebral microcirculation." Trends in cardiovascular medicine vol. 17,6 (2007): 183-90. doi: https://doi.org/10.1016/j.tcm.2007.05.001
Straub SV, Nelson MT. Astrocytic calcium signaling: the information currency coupling neuronal activity to the cerebral microcirculation. Trends Cardiovasc Med. 2007 Aug;17(6):183-90. doi: 10.1016/j.tcm.2007.05.001. PMID: 17662912; PMCID: PMC1987323.
Copy Download .nbib Format: NLM
Share it on

Trends Cardiovasc Med. 2007 Aug;17(6):183-90. doi: 10.1016/j.tcm.2007.05.001.

Astrocytic calcium signaling: the information currency coupling neuronal activity to the cerebral microcirculation.

Trends in cardiovascular medicine

Stephen V Straub, Mark T Nelson

Affiliations

  1. Department of Pharmacology, University of Vermont, Burlington, VT 05405, USA. [email protected]

PMID: 17662912 PMCID: PMC1987323 DOI: 10.1016/j.tcm.2007.05.001

Abstract

In the brain, increased neuronal synaptic activity is accompanied by an increase in local cerebral blood flow that serves to satisfy neuronal metabolic demands. This linkage between neuronal activity and local blood flow has been appreciated for more than 100 years. Although this process has been exploited clinically in the form of functional imaging techniques to map brain function, the mechanisms by which increased synaptic activity is communicated to the cerebral microcirculation to generate a vasodilatory response are poorly understood. Recent studies, however, have illuminated a central role for astrocytic calcium (Ca(2+)) signals as mediators of this process of neurovascular coupling. This review highlights recent evidence implicating astrocytes in the regulation of intracerebral arteriolar diameter, with particular emphasis on the putative signaling molecules and pathways proposed to exert changes on arteriolar physiology.

References

  1. Circ Res. 2004 Nov 12;95(10):e73-81 - PubMed
  2. Circ Res. 1984 Aug;55(2):197-202 - PubMed
  3. Exp Physiol. 2005 Jan;90(1):131-40 - PubMed
  4. Cell Calcium. 2005 Sep-Oct;38(3-4):375-82 - PubMed
  5. J Appl Physiol (1985). 2006 Jan;100(1):318-27 - PubMed
  6. Stroke. 1996 May;27(5):971-9 - PubMed
  7. Nat Neurosci. 2006 Nov;9(11):1397-1403 - PubMed
  8. Circ Res. 2005 Oct 28;97(9):908-15 - PubMed
  9. Physiol Rev. 2002 Jan;82(1):131-85 - PubMed
  10. Brain Res. 2002 Nov 29;956(2):183-93 - PubMed
  11. Nat Neurosci. 2003 Jan;6(1):43-50 - PubMed
  12. Nat Rev Neurosci. 2004 May;5(5):347-60 - PubMed
  13. Anesth Analg. 2006 Feb;102(2):571-6 - PubMed
  14. Glia. 1998 May;23(1):1-10 - PubMed
  15. Stroke. 1998 Jan;29(1):229-34 - PubMed
  16. J Physiol. 1999 Mar 15;515 ( Pt 3):639-51 - PubMed
  17. Mol Interv. 2003 Mar;3(2):79-89, 51 - PubMed
  18. Nature. 2004 Sep 9;431(7005):195-9 - PubMed
  19. Am J Physiol. 1995 Jul;269(1 Pt 2):H348-55 - PubMed
  20. J Neurosci. 2006 Mar 15;26(11):2862-70 - PubMed
  21. Physiol Rev. 1998 Jan;78(1):99-141 - PubMed
  22. Cell Calcium. 2004 Jan;35(1):47-58 - PubMed
  23. J Neurosci. 2006 Jun 28;26(26):6997-7006 - PubMed
  24. Neuroimage. 1996 Dec;4(3 Pt 1):183-93 - PubMed
  25. J Appl Physiol (1985). 2006 Mar;100(3):1059-64 - PubMed
  26. Contemp Top Lab Anim Sci. 2002 May;41(3):28-32 - PubMed
  27. J Physiol. 1890 Jan;11(1-2):85-158.17 - PubMed
  28. Brain Res. 2002 Sep 6;948(1-2):108-16 - PubMed
  29. Am J Physiol. 1995 Jan;268(1 Pt 1):C259-70 - PubMed
  30. Auton Neurosci. 2002 Jan 10;95(1-2):137-40 - PubMed
  31. Pflugers Arch. 2007 Sep;454(6):891-902 - PubMed
  32. J Neurosci. 2003 Mar 1;23(5):1678-87 - PubMed
  33. J Physiol. 2002 Dec 1;545(Pt 2):615-27 - PubMed
  34. J Physiol. 1902 May 28;28(3):220-31 - PubMed
  35. Glia. 2000 Jul;31(1):15-28 - PubMed
  36. Science. 1997 Mar 14;275(5306):1643-8 - PubMed
  37. Anesthesiology. 2003 Dec;99(6):1333-9 - PubMed
  38. Circ Res. 1996 Jan;78(1):148-53 - PubMed
  39. Acta Anaesthesiol Scand. 1992 May;36(4):318-22 - PubMed
  40. Microvasc Res. 1990 Mar;39(2):129-39 - PubMed
  41. J Neurosci. 2003 Oct 8;23(27):9254-62 - PubMed
  42. J Physiol. 1996 Apr 15;492 ( Pt 2):419-30 - PubMed
  43. Neuroscience. 2004;129(4):1045-56 - PubMed
  44. Nat Neurosci. 1998 Dec;1(8):683-92 - PubMed
  45. Can J Physiol Pharmacol. 1999 Jul;77(7):481-9 - PubMed
  46. Nat Neurosci. 2006 Feb;9(2):260-7 - PubMed
  47. J Physiol. 1998 Apr 1;508 ( Pt 1):199-209 - PubMed
  48. Nat Neurosci. 1999 Feb;2(2):139-43 - PubMed
  49. Circ Res. 2005 Dec 9;97(12):1270-9 - PubMed
  50. J Neurosci. 1999 Aug 15;19(16):6897-906 - PubMed
  51. Science. 1986 Jul 25;233(4762):453-4 - PubMed
  52. J Neurosci. 2004 Oct 13;24(41):8940-9 - PubMed
  53. Science. 1992 Apr 24;256(5056):532-5 - PubMed
  54. Circ Res. 2000 Jul 21;87(2):160-6 - PubMed
  55. Physiol Rev. 1997 Oct;77(4):1165-232 - PubMed
  56. J Gen Physiol. 2006 Dec;128(6):659-69 - PubMed
  57. Science. 1990 Jan 26;247(4941):470-3 - PubMed
  58. Trends Neurosci. 2003 Jul;26(7):340-4; author reply 344-5 - PubMed
  59. J Neurosci. 2005 Mar 16;25(11):2906-16 - PubMed
  60. Trends Neurosci. 1999 May;22(5):208-15 - PubMed
  61. Am J Physiol. 1990 Sep;259(3 Pt 2):H902-8 - PubMed
  62. J Neurosci. 2007 Apr 11;27(15):4036-44 - PubMed
  63. Circ Res. 2001 Mar 30;88(6):600-8 - PubMed
  64. J Physiol. 2003 Dec 1;553(Pt 2):407-14 - PubMed
  65. Prog Neurobiol. 1997 Mar;51(4):439-55 - PubMed

Substances

MeSH terms

Publication Types

Grant support