BMC Neurosci. 2007 Mar 26;8:23. doi: 10.1186/1471-2202-8-23.
Modulation of quinpirole-induced compulsive-like behavior in rats by environmental changes: implications for OCD rituals and for exploration and navigation.
BMC neuroscience
Pazit Zadicario, Sharon Ronen, David Eilam
PMID: 17386094
PMCID: PMC1847440 DOI: 10.1186/1471-2202-8-23
Abstract
BACKGROUND: Rats treated chronically with the D2-3 dopamine agonist quinpirole were previously proposed as an animal model of obsessive-compulsive disorder (OCD) since their behavior is based on repeated, compulsive-like persistent traveling between a few places in the open field. The aim of the present study was to determine properties of the physical environment that shape such behavior. For this, quinpirole-treated rats were first exposed to an arena with an array of objects (landmarks) and after the development of compulsive-like behavior, the arena was manipulated by multiplying the number of objects, changing their spacing, relocating object array, or removing the objects.
RESULTS: When the number of objects was retained but they were spaced further apart, rat routes converged at 1-2 of the objects and at the corner at which the rats had been introduced into the arena (start corner). When object spacing was retained but their number was increased, the rats traveled between the objects with the routes converging only at the start corner. Finally, when object array was relocated to different places within the arena, the rats extended their routes from the start corner to the object array, regardless of array location.
CONCLUSION: Quinpirole-treated rats organized and updated their progression primarily according to the proximal layout of landmarks, but did so with excessive repetitions compared with saline-treated rats. The behavior of quinpirole-treated rats paralleled human OCD rituals that are linked to the immediate physical environment, featuring an excessive rate of performance. Finally, when only a few objects were present, they were perceived by the rats as positional cues (beacons) that routes converged at them. In contrast, in the presence of many objects, the routes passed between the objects as if using them as directional cues.
References
- Neurosci Biobehav Rev. 2001 Jul;25(5):409-26 - PubMed
- World J Biol Psychiatry. 2009;10(4 Pt 2):480-7 - PubMed
- Exp Brain Res. 2002 Apr;143(4):470-9 - PubMed
- Behav Brain Res. 2003 Apr 17;141(1):73-81 - PubMed
- Psychol Rev. 2003 Apr;110(2):285-315 - PubMed
- Pharmacol Biochem Behav. 2004 Aug;78(4):661-6 - PubMed
- Behav Brain Res. 2004 Oct 5;154(2):345-52 - PubMed
- Cognition. 1986 Jul;23(2):149-78 - PubMed
- Annu Rev Psychol. 1989;40:155-89 - PubMed
- Eur J Pharmacol. 1989 Feb 28;161(2-3):151-7 - PubMed
- Brain Res. 1989 Jun 26;490(2):255-67 - PubMed
- Behav Brain Res. 1989 Sep 1;34(3):199-211 - PubMed
- Behav Brain Res. 1991 Nov 26;45(2):117-24 - PubMed
- Psychopharmacology (Berl). 1994 Jun;115(1-2):95-104 - PubMed
- Physiol Behav. 1995 Jan;57(1):55-9 - PubMed
- J Exp Biol. 1996 Jan;199(Pt 1):201-9 - PubMed
- Physiol Behav. 1998 May;64(2):203-7 - PubMed
- Behav Neurosci. 1998 Dec;112(6):1475-85 - PubMed
- CNS Spectr. 2005 Mar;10(3):191-202 - PubMed
- Neurosci Biobehav Rev. 2005 May;29(3):399-419 - PubMed
- J Exp Psychol Anim Behav Process. 2005 Apr;31(2):142-54 - PubMed
- Biol Psychiatry. 2005 May 15;57(10):1176-85 - PubMed
- Psychon Bull Rev. 2005 Feb;12(1):1-23 - PubMed
- Physiol Behav. 2006 Apr 15;87(4):805-16 - PubMed
- Neurosci Biobehav Rev. 2006;30(4):456-71 - PubMed
- Behav Brain Res. 2006 Aug 10;171(2):230-9 - PubMed
- Anim Cogn. 2007 Oct;10(4):415-28 - PubMed
- Behav Brain Sci. 2006 Dec;29(6):595-613; discussion 613-50 - PubMed
- Behav Neurosci. 2001 Dec;115(6):1301-17 - PubMed
Substances
MeSH terms
Publication Types