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Ghazi-Khansari M, Mohammadi-Karakani A, Sotoudeh M, et al. Antifibrotic effect of captopril and enalapril on paraquat-induced lung fibrosis in rats. J Appl Toxicol. 2007;27(4):342-9doi: 10.1002/jat.1212.
Ghazi-Khansari, M., Mohammadi-Karakani, A., Sotoudeh, M., Mokhtary, P., Pour-Esmaeil, E., & Maghsoud, S. (2007). Antifibrotic effect of captopril and enalapril on paraquat-induced lung fibrosis in rats. Journal of applied toxicology : JAT, 27(4), 342-9. https://doi.org/10.1002/jat.1212
Ghazi-Khansari, Mahmoud, et al. "Antifibrotic effect of captopril and enalapril on paraquat-induced lung fibrosis in rats." Journal of applied toxicology : JAT vol. 27,4 (2007): 342-9. doi: https://doi.org/10.1002/jat.1212
Ghazi-Khansari M, Mohammadi-Karakani A, Sotoudeh M, Mokhtary P, Pour-Esmaeil E, Maghsoud S. Antifibrotic effect of captopril and enalapril on paraquat-induced lung fibrosis in rats. J Appl Toxicol. 2007 Jul-Aug;27(4):342-9. doi: 10.1002/jat.1212. PMID: 17265423.
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J Appl Toxicol. 2007 Jul-Aug;27(4):342-9. doi: 10.1002/jat.1212.

Antifibrotic effect of captopril and enalapril on paraquat-induced lung fibrosis in rats.

Journal of applied toxicology : JAT

Mahmoud Ghazi-Khansari, Ali Mohammadi-Karakani, Masoud Sotoudeh, Parvin Mokhtary, Ebraheim Pour-Esmaeil, Shirin Maghsoud

Affiliations

  1. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. [email protected]

PMID: 17265423 DOI: 10.1002/jat.1212

Abstract

Although different treatment modalities have been implemented for pulmonary fibrosis, the results have not been promising and these conditions have been considered untreatable and irreversible. Thus, a plethora of new drugs has been tried for the control of this condition in recent years. This study examined the effects of two angiotensin-converting enzyme inhibitors, captopril and enalapril, on paraquat-induced pulmonary fibrosis in rats, through biochemical and histopathological parameters. Male albino Wistar rats were divided into eight groups (n = 4-5 each), including control, paraquat, captopril alone, captopril treatment and pre-treatment, enalapril alone, enalapril treatment and pre-treatment. After 21 days of treatment, the lungs were removed and the levels of hydroxyproline, glutathione and lipid peroxidation were determined. Angiotensin-converting enzyme inhibitors showed no effect on glutathione and lipid peroxidation. The results also demonstrated that captopril and enalapril improved pulmonary fibrosis as shown by histopathology, as well as a decreased content of hydroxyproline (P < 0.001) in the lung tissue. In conclusion, the present findings suggest that the antifibrotic effect of these drugs may be related to the inhibition of angiotensin-converting enzyme.

Copyright (c) 2007 John Wiley & Sons, Ltd.

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