Display options
Cite
Simms AE, Paton JF, Pickering AE. Hierarchical recruitment of the sympathetic and parasympathetic limbs of the baroreflex in normotensive and spontaneously hypertensive rats. J Physiol. 2006;579:473-86doi: 10.1113/jphysiol.2006.124396.
Simms, A. E., Paton, J. F., & Pickering, A. E. (2007). Hierarchical recruitment of the sympathetic and parasympathetic limbs of the baroreflex in normotensive and spontaneously hypertensive rats. The Journal of physiology, 579473-86. https://doi.org/10.1113/jphysiol.2006.124396
Simms, Annabel E, et al. "Hierarchical recruitment of the sympathetic and parasympathetic limbs of the baroreflex in normotensive and spontaneously hypertensive rats." The Journal of physiology vol. 579 (2007): 473-86. doi: https://doi.org/10.1113/jphysiol.2006.124396
Simms AE, Paton JF, Pickering AE. Hierarchical recruitment of the sympathetic and parasympathetic limbs of the baroreflex in normotensive and spontaneously hypertensive rats. J Physiol. 2007 Mar 01;579:473-86. doi: 10.1113/jphysiol.2006.124396. Epub 2006 Dec 14. PMID: 17170043; PMCID: PMC1865002.
Copy Download .nbib Format: NLM
Share it on

J Physiol. 2007 Mar 01;579:473-86. doi: 10.1113/jphysiol.2006.124396. Epub 2006 Dec 14.

Hierarchical recruitment of the sympathetic and parasympathetic limbs of the baroreflex in normotensive and spontaneously hypertensive rats.

The Journal of physiology

Annabel E Simms, Julian F R Paton, Anthony E Pickering

Affiliations

  1. Department of Physiology, Bristol Heart Institute, School of Medical Sciences, University Walk, University of Bristol, Bristol BS8 1TD, UK.

PMID: 17170043 PMCID: PMC1865002 DOI: 10.1113/jphysiol.2006.124396

Abstract

The arterial baroreflex acts to buffer acute changes in blood pressure by reciprocal modulation of sympathetic and parasympathetic activity that controls the heart and vasculature. We have examined the baroreflex pressure-function curves for changes in heart rate and non-cardiac sympathetic nerve activity (SNA, thoracic chain T8-12) in artificially perfused in situ rat preparations. We found that the non-cardiac SNA baroreflex is active over a lower range of pressures than the cardiac baroreflex (threshold 66 +/- 1 mmHg versus 82 +/- 5 mmHg and mid-point 77 +/- 3 versus 87 +/- 4 mmHg, respectively, P < 0.05, n = 6). This can manifest as a complete dissociation of the baroreflex limbs at low pressures. This difference between the cardiac and non-cardiac SNA baroreflex is also seen in end-organ sympathetic outflows (adrenal and renal nerves). Recordings of the cardiac vagal (parasympathetic) and the inferior cardiac (sympathetic) nerves identify the cardiac parasympathetic baroreflex component as being active over a higher range of pressures. This difference in the operating range of the baroreflex-function curves is exaggerated in the spontaneously hypertensive rat where the cardiac component has selectively reset by 20-25 mmHg to a higher pressure range (threshold of 104 +/- 4 mmHg and mid-point 113 +/- 4, n = 6). The difference in the pressure-function curves for the cardiac versus the vascular baroreflex indicates that there is a hierarchical recruitment of the output limbs of the baroreflex with a sympathetic predominance at lower arterial pressures.

References

  1. Circ Res. 1965 Apr;16:363-75 - PubMed
  2. J Physiol. 1978 Jan;274:621-37 - PubMed
  3. Proc Natl Acad Sci U S A. 1988 Oct;85(19):7399-403 - PubMed
  4. Am J Physiol. 1991 Jan;260(1 Pt 2):H300-3 - PubMed
  5. J Physiol. 1970 Aug;209(2):257-93 - PubMed
  6. Brain Res. 1998 Oct 19;808(2):238-49 - PubMed
  7. J Physiol. 2003 Sep 1;551(Pt 2):589-99 - PubMed
  8. J Neurosci Methods. 2006 Sep 15;155(2):260-71 - PubMed
  9. Am J Physiol. 1971 Nov;221(5):1346-51 - PubMed
  10. J Physiol. 2006 Sep 15;575(Pt 3):727-38 - PubMed
  11. Exp Physiol. 2006 Jan;91(1):37-49 - PubMed
  12. Am J Physiol Regul Integr Comp Physiol. 2005 Apr;288(4):R856-62 - PubMed
  13. Am J Physiol. 1989 Jun;256(6 Pt 2):H1735-41 - PubMed
  14. Hypertension. 1998 Jan;31(1):68-72 - PubMed
  15. J Auton Nerv Syst. 1987 Aug;20(2):121-7 - PubMed
  16. J Physiol. 1932 Feb 8;74(2):115-33 - PubMed
  17. Am J Physiol Regul Integr Comp Physiol. 2000 Nov;279(5):R1910-21 - PubMed
  18. Am J Physiol Heart Circ Physiol. 2001 May;280(5):H2061-8 - PubMed
  19. J Physiol. 2000 Dec 1;529 Pt 2:431-43 - PubMed
  20. Am J Physiol. 1999 Sep;277(3 Pt 2):R748-56 - PubMed
  21. Am J Physiol Heart Circ Physiol. 2007 Jan;292(1):H593-600 - PubMed
  22. Cardiology. 1972;57(5):295-310 - PubMed
  23. Neuroscience. 2001;103(1):153-60 - PubMed
  24. Clin Exp Pharmacol Physiol. 1988 Apr;15(4):289-92 - PubMed
  25. Am J Med Sci. 1988 Apr;295(4):327-34 - PubMed
  26. Circulation. 2000 Nov 21;102(21):2611-8 - PubMed
  27. Ann N Y Acad Sci. 2001 Jun;940:157-68 - PubMed
  28. J Neurosci Methods. 1996 Mar;65(1):63-8 - PubMed
  29. Am J Physiol Regul Integr Comp Physiol. 2006 Apr;290(4):R1020-6 - PubMed
  30. J Auton Nerv Syst. 1998 Aug 6;72(1):46-54 - PubMed
  31. Acta Physiol Scand. 1988 Jun;133(2):221-31 - PubMed
  32. J Hypertens. 2002 Sep;20(9):1675-88 - PubMed
  33. Am J Physiol. 1998 Mar;274(3 Pt 2):H794-800 - PubMed
  34. Am J Physiol. 1999 May;276(5 Pt 2):H1691-8 - PubMed
  35. J Physiol. 1971 Jun;215(2):521-38 - PubMed
  36. Am J Physiol. 1992 May;262(5 Pt 2):H1372-8 - PubMed
  37. J Physiol. 2005 Oct 1;568(Pt 1):315-21 - PubMed
  38. J Neurophysiol. 1994 Nov;72(5):2222-36 - PubMed
  39. Clin Exp Pharmacol Physiol. 1992 Aug;19(8):587-97 - PubMed
  40. Prog Neurobiol. 1998 Oct;56(1):65-96 - PubMed
  41. J Physiol. 1999 Nov 15;521 Pt 1:213-25 - PubMed
  42. J Physiol. 1952 Dec;118(4):509-19 - PubMed
  43. Circ Res. 1978 Nov;43(5):728-38 - PubMed
  44. J Physiol. 2003 Apr 1;548(Pt 1):313-22 - PubMed

MeSH terms

Publication Types

Grant support