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Chu CQ, Field M, Abney E, et al. Transforming growth factor-beta 1 in rheumatoid synovial membrane and cartilage/pannus junction. Clin Exp Immunol. 1991;86(3):380-6doi: 10.1111/j.1365-2249.1991.tb02941.x.
Chu, C. Q., Field, M., Abney, E., Zheng, R. Q., Allard, S., Feldmann, M., & Maini, R. N. (1991). Transforming growth factor-beta 1 in rheumatoid synovial membrane and cartilage/pannus junction. Clinical and experimental immunology, 86(3), 380-6. https://doi.org/10.1111/j.1365-2249.1991.tb02941.x
Chu, C Q, et al. "Transforming growth factor-beta 1 in rheumatoid synovial membrane and cartilage/pannus junction." Clinical and experimental immunology vol. 86,3 (1991): 380-6. doi: https://doi.org/10.1111/j.1365-2249.1991.tb02941.x
Chu CQ, Field M, Abney E, Zheng RQ, Allard S, Feldmann M, Maini RN. Transforming growth factor-beta 1 in rheumatoid synovial membrane and cartilage/pannus junction. Clin Exp Immunol. 1991 Dec;86(3):380-6. doi: 10.1111/j.1365-2249.1991.tb02941.x. PMID: 1747946; PMCID: PMC1554206.
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Clin Exp Immunol. 1991 Dec;86(3):380-6. doi: 10.1111/j.1365-2249.1991.tb02941.x.

Transforming growth factor-beta 1 in rheumatoid synovial membrane and cartilage/pannus junction.

Clinical and experimental immunology

C Q Chu, M Field, E Abney, R Q Zheng, S Allard, M Feldmann, R N Maini

Affiliations

  1. Clinical Immunology Division, Kennedy Institute of Rheumatology, Hammersmith, London, UK.

PMID: 1747946 PMCID: PMC1554206 DOI: 10.1111/j.1365-2249.1991.tb02941.x
Free PMC Article

Abstract

Transforming growth factor (TGF)-beta has been shown to promote tissue repair and have immunosuppressive actions, and has been proposed to have a role in rheumatoid arthritis (RA). Using immunohistochemical techniques with rabbit F(ab')2 antibodies raised against recombinant human TGF-beta 1, we have detected TGF-beta 1 in the synovial tissue and cartilage/pannus junction (CPJ) from 18/18 patients with RA. TGF-beta 1 was found predominantly in the thickened synovial lining layer in RA, but also detected in a perivascular pattern in the synovial interstitium as well as in occasional cells in the lymphoid aggregates. At the CPJ it was found both in cells at the distinct junction as well as in the transitional region of the diffuse fibroblastic zone. The cells staining for TGF-beta 1 were identified by double immunofluorescence staining as being from the monocyte/macrophage series as well as the type B synovial lining cells. TGF-beta 1 was also detected in the synovial membrane sections from 4/4 patients with systemic lupus erythematosus/mixed connective tissue disease and 5/8 patients with osteoarthritis, in a similar distribution to that seen in RA, and in the lining layer of 1/7 normal synovial membranes. These results add to histological evidence confirming that TGF-beta 1 is present in RA synovial cells and those from other arthritides. The distributions of TGF-beta 1 in RA synovial membrane reflects its known actions, as it can be detected at the CPJ, where it could induce repair, and close to activated cells upon which it may exert an immunosuppressive action.

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