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Jackson HC, Griffin IJ, Nutt DJ. The effects of idazoxan and other alpha 2-adrenoceptor antagonists on food and water intake in the rat. Br J Pharmacol. 1991;104(1):258-62doi: 10.1111/j.1476-5381.1991.tb12416.x.
Jackson, H. C., Griffin, I. J., & Nutt, D. J. (1991). The effects of idazoxan and other alpha 2-adrenoceptor antagonists on food and water intake in the rat. British journal of pharmacology, 104(1), 258-62. https://doi.org/10.1111/j.1476-5381.1991.tb12416.x
Jackson, H C, et al. "The effects of idazoxan and other alpha 2-adrenoceptor antagonists on food and water intake in the rat." British journal of pharmacology vol. 104,1 (1991): 258-62. doi: https://doi.org/10.1111/j.1476-5381.1991.tb12416.x
Jackson HC, Griffin IJ, Nutt DJ. The effects of idazoxan and other alpha 2-adrenoceptor antagonists on food and water intake in the rat. Br J Pharmacol. 1991 Sep;104(1):258-62. doi: 10.1111/j.1476-5381.1991.tb12416.x. PMID: 1686207; PMCID: PMC1908278.
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Br J Pharmacol. 1991 Sep;104(1):258-62. doi: 10.1111/j.1476-5381.1991.tb12416.x.

The effects of idazoxan and other alpha 2-adrenoceptor antagonists on food and water intake in the rat.

British journal of pharmacology

H C Jackson, I J Griffin, D J Nutt

Affiliations

  1. Department of Pharmacology, School of Medical Sciences, University Walk, Bristol.

PMID: 1686207 PMCID: PMC1908278 DOI: 10.1111/j.1476-5381.1991.tb12416.x
Free PMC Article

Abstract

1. Idazoxan (1, 3, 10 mg kg-1, i.p.) produced a significant increase in food and water intake in freely feeding rats during the daylight phase. 2. The more selective and specific alpha 2-adrenoceptor antagonists, RX811059 (0.3, 1, 3 mg kg-1, i.p.) and RX821002 (0.3, 1, 3 mg kg-1, i.p.), did not produce hyperphagia in rats, however, the highest dose produced a significant increase in water intake. 3. The peripherally acting alpha 2-adrenoceptor antagonist, L-659,066 (1, 3, 10 mg kg-1, i.p.), did not affect food intake in the 4 h following injection, but the highest dose (10 mg kg-1), produced a large increase in water intake. 4. These results indicate that alpha 2-adrenoceptor antagonists may increase water intake by a peripherally mediated mechanism. 5. The lack of effect RX811059 and RX821002 on food intake contrasts with the large dose-related increases induced by idazoxan and suggests that the hyperphagic effects of idazoxan are not due to alpha 2-adrenoceptor blockade but may instead reflect its affinity for a non-adrenoceptor site, a property not shared by the other alpha 2-antagonists.

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