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Yang YS, Peng CH, Sia SK, et al. Acquired hypophosphatemia osteomalacia associated with Fanconi's syndrome in Sjögren's syndrome. Rheumatol Int. 2006;27(6):593-7doi: 10.1007/s00296-006-0257-6.
Yang, Y. S., Peng, C. H., Sia, S. K., & Huang, C. N. (2007). Acquired hypophosphatemia osteomalacia associated with Fanconi's syndrome in Sjögren's syndrome. Rheumatology international, 27(6), 593-7. https://doi.org/10.1007/s00296-006-0257-6
Yang, Yi-Sun, et al. "Acquired hypophosphatemia osteomalacia associated with Fanconi's syndrome in Sjögren's syndrome." Rheumatology international vol. 27,6 (2007): 593-7. doi: https://doi.org/10.1007/s00296-006-0257-6
Yang YS, Peng CH, Sia SK, Huang CN. Acquired hypophosphatemia osteomalacia associated with Fanconi's syndrome in Sjögren's syndrome. Rheumatol Int. 2007 Apr;27(6):593-7. doi: 10.1007/s00296-006-0257-6. Epub 2006 Nov 09. PMID: 17094001.
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Rheumatol Int. 2007 Apr;27(6):593-7. doi: 10.1007/s00296-006-0257-6. Epub 2006 Nov 09.

Acquired hypophosphatemia osteomalacia associated with Fanconi's syndrome in Sjögren's syndrome.

Rheumatology international

Yi-Sun Yang, Chiung-Huei Peng, Sung-Kien Sia, Chien-Ning Huang

Affiliations

  1. Division of Endocrinology and Metabolism, Department of Internal Medicine, Chung-Shan Medical University Hospital, Chung Shan Medical University, 110 Sec. 1, Chien Kuo N. Road, Taichung , 402, Taiwan.

PMID: 17094001 DOI: 10.1007/s00296-006-0257-6

Abstract

Sjögren's syndrome is an autoimmune disorder involving exocrine glands that occurs alone or in association with various autoimmune and connective tissue diseases. The severity of Sjögren's syndrome ranges from isolated sicca syndrome to severe complications such as vasculitis, lung and renal involvement. Overt or latent renal tubular acidosis caused by autoimmune tubulointerstitial nephritis, is a common extraglandular manifestation in Sjögren's syndrome. Osteomalacia is a rare complication of renal tubular acidosis, and it was reported to be associated with distal renal tubular acidosis in Sjögren's syndrome. We report a 60-year-old woman who presented with multiple bone deformity and general muscle weakness. Osteomalacia was secondary to Fanconi's syndrome, and the Fanconi's syndrome was a result of renal involvement in Sjögren's syndrome. Fanconi's syndrome is a rare kidney manifestation in Sjögren's syndrome. It may be latent and may precede the subjective sicca symptoms. These findings suggest that evidence for Sjögren's syndrome should be sought in adult patients with unexplained osteomalacia and renal tubular acidosis, even in the absence of subjective sicca syndrome. Conversely, in patients with Sjögren's syndrome, early investigation and treatment of renal tubular dysfunction may prevent future complications, such as osteomalacia.

References

  1. Vojnosanit Pregl. 2005 Oct;62(10):769-73 - PubMed
  2. Medicine (Baltimore). 2000 Jul;79(4):241-9 - PubMed
  3. Nephron. 1971;8(1):103-7 - PubMed
  4. Clin Endocrinol (Oxf). 1995 Oct;43(4):479-90 - PubMed
  5. Joint Bone Spine. 2005 Oct;72(5):424-6 - PubMed
  6. Rev Rhum Engl Ed. 1995 Jul-Sep;62(7-8):529-32 - PubMed
  7. Br J Clin Pract. 1988 Oct;42(10):436-8 - PubMed
  8. J Rheumatol Suppl. 1997 Sep;50:8-11 - PubMed
  9. Arthritis Rheum. 1993 Dec;36(12):1735-8 - PubMed
  10. Clin Nephrol. 2004 Jun;61(6):434-9 - PubMed
  11. Nephron. 1972;9(4):208-19 - PubMed
  12. Arch Intern Med. 2004 Apr 26;164(8):905-9 - PubMed
  13. Ryumachi. 1991 Feb;31(1):45-53; discussion 50-2 - PubMed
  14. Am J Med. 1965 Aug;39:312-8 - PubMed
  15. Ann Rheum Dis. 1987 Oct;46(10):768-72 - PubMed
  16. J Rheumatol. 1995 Dec;22(12):2366-8 - PubMed
  17. Nephrol Dial Transplant. 2001 Dec;16(12):2328-36 - PubMed
  18. Medicine (Baltimore). 1965 May;44:187-231 - PubMed
  19. Clin Exp Rheumatol. 1991 Nov-Dec;9(6):625-7 - PubMed
  20. Sem Hop. 1983 Jun 2;59(22):1693-8 - PubMed
  21. J Intern Med. 1996 Jun;239(6):483-8 - PubMed
  22. J Intern Med. 1991 Aug;230(2):187-91 - PubMed

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