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Elsevier Science

Brain Res Bull. 1991 Nov;27(5):743-6. doi: 10.1016/0361-9230(91)90057-q.

Quinpirole to the accumbens reduces exploratory and amphetamine-elicited locomotion.

Brain research bulletin

G J Mogenson, M Wu

Affiliations

  1. Department of Physiology, University of Western Ontario, London, Canada.

PMID: 1684529 DOI: 10.1016/0361-9230(91)90057-q

Abstract

Locomotor activity measured in an open-field apparatus was increased by adding partitions to enhance exploratory locomotion and by injecting amphetamine into the nucleus accumbens. Administration of the dopamine D2 agonist, quinpirole, into the nucleus accumbens reduced significantly both exploratory and amphetamine-elicited locomotion. It is suggested that these effects of quinpirole are mediated by different presynaptic mechanisms.

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