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Lubbe WF, McFadyen ML, Muller CA, et al. Protective action of amiodarone against ventricular fibrillation in the isolated perfused rat heart. Am J Cardiol. 1979;43(3):533-40doi: 10.1016/0002-9149(79)90010-9.
Lubbe, W. F., McFadyen, M. L., Muller, C. A., Worthington, M., & Opie, L. H. (1979). Protective action of amiodarone against ventricular fibrillation in the isolated perfused rat heart. The American journal of cardiology, 43(3), 533-40. https://doi.org/10.1016/0002-9149(79)90010-9
Lubbe, W F, et al. "Protective action of amiodarone against ventricular fibrillation in the isolated perfused rat heart." The American journal of cardiology vol. 43,3 (1979): 533-40. doi: https://doi.org/10.1016/0002-9149(79)90010-9
Lubbe WF, McFadyen ML, Muller CA, Worthington M, Opie LH. Protective action of amiodarone against ventricular fibrillation in the isolated perfused rat heart. Am J Cardiol. 1979 Mar;43(3):533-40. doi: 10.1016/0002-9149(79)90010-9. PMID: 217261.
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Elsevier Science

Am J Cardiol. 1979 Mar;43(3):533-40. doi: 10.1016/0002-9149(79)90010-9.

Protective action of amiodarone against ventricular fibrillation in the isolated perfused rat heart.

The American journal of cardiology

W F Lubbe, M L McFadyen, C A Muller, M Worthington, L H Opie

PMID: 217261 DOI: 10.1016/0002-9149(79)90010-9

Abstract

The pretreatment of rats with amiodarone for 2 minutes to 3 weeks before the excision of their hearts caused a dose-related decrease in heart rate and an increase in the ventricular fibrillation threshold both before and after coronary arterial ligation. Similarly, amiodarone decreased the incidence of ventricular premature extrasystoles, ventricular tachycardia and fibrillation during the period of regional ischemia after coronary arterial ligation and also after reperfusion of the ischemic myocardium. There was no evidence of a metabolic protective effect on ischemic myocardium because tissue high energy phosphate content decreased to a similar extent in ischemic myocardium from control and amiodarone-treated rats. Instead, the protective effect of amiodarone against fibrillation was accompanied by attenuation of the increase in tissue cyclic adenosine monophosphate in ischemic myocardium after coronary arterial ligation. It is proposed that amiodarone exerts a potent antifibrillatory effect by decreasing tissue cyclic adenosine monophosphate in ischemic myocardium.

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