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Moran-Gates T, Massari C, Graulich A, et al. Long-term effects of JL 13, a potential atypical antipsychotic, on rat dopamine and serotonin receptor subtypes. J Neurosci Res. 2006;84(3):675-82doi: 10.1002/jnr.20972.
Moran-Gates, T., Massari, C., Graulich, A., Liégeois, J. F., & Tarazi, F. I. (2006). Long-term effects of JL 13, a potential atypical antipsychotic, on rat dopamine and serotonin receptor subtypes. Journal of neuroscience research, 84(3), 675-82. https://doi.org/10.1002/jnr.20972
Moran-Gates, Taylor, et al. "Long-term effects of JL 13, a potential atypical antipsychotic, on rat dopamine and serotonin receptor subtypes." Journal of neuroscience research vol. 84,3 (2006): 675-82. doi: https://doi.org/10.1002/jnr.20972
Moran-Gates T, Massari C, Graulich A, Liégeois JF, Tarazi FI. Long-term effects of JL 13, a potential atypical antipsychotic, on rat dopamine and serotonin receptor subtypes. J Neurosci Res. 2006 Aug 15;84(3):675-82. doi: 10.1002/jnr.20972. PMID: 16810690.
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J Neurosci Res. 2006 Aug 15;84(3):675-82. doi: 10.1002/jnr.20972.

Long-term effects of JL 13, a potential atypical antipsychotic, on rat dopamine and serotonin receptor subtypes.

Journal of neuroscience research

Taylor Moran-Gates, Carla Massari, Amaury Graulich, Jean-François Liégeois, Frank I Tarazi

Affiliations

  1. Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont, Massachusetts 02478, USA.

PMID: 16810690 DOI: 10.1002/jnr.20972

Abstract

Changes in dopamine (DA) D(1), D(2), D(3), and D(4) receptors and serotonin 5-HT(1A) and 5-HT(2A) receptors in rat forebrain regions were autoradiographically quantified after continuous infusion of JL 13 [(5-(4-methylpiperazin-1-yl)-8-chloro-pyrido[2,3-b][1,5]benzoxazepine fumarate] for 28 days with osmotic minipumps and compared with the effects of other typical (fluphenazine) and atypical (clozapine, olanzapine, and risperidone) antipsychotic drugs from previous studies. Similar to other typical and atypical antipsychotics, JL 13 increased labeling of D(2) receptors in medial prefrontal cortex (MPC) and hippocampus (HIP) and D(4) receptors in nucleus accumbens (NAc), caudate-putamen (CPu), and HIP. In addition, JL 13 increased 5-HT(1A) and decreased 5-HT(2A) receptors in MPC and dorsolateral frontal cortex (DFC), an effect shared by atypical antipsychotics, and may contribute to their psychopharmacological properties. Clozapine and JL 13, but not other antipsychotics, spared D(2) receptors in CPu, which may reflect their ability to induce minimal extrapyramidal side effects. In addition, JL 13 but not other typical and atypical antipsychotic drugs increased abundance of D(1) receptors in CPu and NAc. JL 13 as well as other antipsychotic agents did not alter levels of forebrain D(3) receptors. An atypical-like profile of JL 13 on DA and 5-HT receptor subtypes should encourage further development of this compound as a novel atypical antipsychotic drug.

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