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Götestam KG, Oppöyen F, Berntzen D. Treatment of insomnia with two benzodiazepines: a double-blind crossover study. Eur J Clin Pharmacol. 1991;41(2):137-40doi: 10.1007/BF00265906.
Götestam, K. G., Oppöyen, F., & Berntzen, D. (1991). Treatment of insomnia with two benzodiazepines: a double-blind crossover study. European journal of clinical pharmacology, 41(2), 137-40. https://doi.org/10.1007/BF00265906
Götestam, K G, et al. "Treatment of insomnia with two benzodiazepines: a double-blind crossover study." European journal of clinical pharmacology vol. 41,2 (1991): 137-40. doi: https://doi.org/10.1007/BF00265906
Götestam KG, Oppöyen F, Berntzen D. Treatment of insomnia with two benzodiazepines: a double-blind crossover study. Eur J Clin Pharmacol. 1991;41(2):137-40. doi: 10.1007/BF00265906. PMID: 1743245.
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Eur J Clin Pharmacol. 1991;41(2):137-40. doi: 10.1007/BF00265906.

Treatment of insomnia with two benzodiazepines: a double-blind crossover study.

European journal of clinical pharmacology

K G Götestam, F Oppöyen, D Berntzen

Affiliations

  1. Department of Psychiatry and Behavioral Medicine, Ostmarka Hospital, University of Trondheim, Norway.

PMID: 1743245 DOI: 10.1007/BF00265906

Abstract

Twenty-eight patients (12 M, 16 F) with insomnia were treated with nitrazepam 5 mg/d and oxazepam 25 mg/d, each for 11 days, in a double-blind crossover comparison with placebo. Half the patients received nitrazepam in the first drug period, and oxazepam in the second and the other half followed the contrary sequence. Both nitrazepam and oxazepam were found to be effective in inducing sleep and increasing sleep quality. No effects on dreaming or adverse effects were found. Nitrazepam did influence the frequency of awakening, but only in the second drug period. In the first period it reduced self-waking. It is concluded that both nitrazepam and oxazepam were effective in inducing sleep and in improving sleep quality.

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