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J Antibiot (Tokyo). 2006 Mar;59(3):137-44. doi: 10.1038/ja.2006.20.

FR209602 and related compounds, novel antifungal lipopeptides from Coleophoma crateriformis no.738. I. Taxonomy, fermentation, isolation and physico-chemical properties.

The Journal of antibiotics

Ryuichi Kanasaki, Kazutoshi Sakamoto, Michizane Hashimoto, Shigehiro Takase, Yasuhisa Tsurumi, Akihiko Fujie, Motohiro Hino, Seiji Hashimoto, Yasuhiro Hori

Affiliations

  1. Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 5-2-3 Tokodai, Tsukuba, Ibaraki 300-2698, Japan. [email protected]

PMID: 16724453 DOI: 10.1038/ja.2006.20

Abstract

Novel antifungal lipopeptides, FR209602, FR209603 and FR209604, were isolated from the fermentation broth of a fungal strain No. 738 which was identified as Coleophoma crateriformis from morphological and physiological characteristics. The antibiotics were purified by solvent extraction, HP-20, YMC-ODS and silica gel column chromatography and lyophilization. These compounds were structurally similar to FR901379 previously reported by ourselves which had a sulfate residue in the cyclic peptide portion.

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