Display options
Cite
Ishida M, Fujiwara H, Kida M, et al. Protective effect of carteolol, a beta-blocker, on myocardial cellular damage in ischemic and reperfused pig hearts: assessment with gated in vivo 31-phosphorus magnetic resonance spectroscopy and electron microscopy. J Mol Cell Cardiol. 1992;24(1):21-34doi: 10.1016/0022-2828(92)91156-y.
Ishida, M., Fujiwara, H., Kida, M., Kawai, C., Nakayama, S., Yamashita, S., Miura, I., & Yabuuchi, Y. (1992). Protective effect of carteolol, a beta-blocker, on myocardial cellular damage in ischemic and reperfused pig hearts: assessment with gated in vivo 31-phosphorus magnetic resonance spectroscopy and electron microscopy. Journal of molecular and cellular cardiology, 24(1), 21-34. https://doi.org/10.1016/0022-2828(92)91156-y
Ishida, M, et al. "Protective effect of carteolol, a beta-blocker, on myocardial cellular damage in ischemic and reperfused pig hearts: assessment with gated in vivo 31-phosphorus magnetic resonance spectroscopy and electron microscopy." Journal of molecular and cellular cardiology vol. 24,1 (1992): 21-34. doi: https://doi.org/10.1016/0022-2828(92)91156-y
Ishida M, Fujiwara H, Kida M, Kawai C, Nakayama S, Yamashita S, Miura I, Yabuuchi Y. Protective effect of carteolol, a beta-blocker, on myocardial cellular damage in ischemic and reperfused pig hearts: assessment with gated in vivo 31-phosphorus magnetic resonance spectroscopy and electron microscopy. J Mol Cell Cardiol. 1992 Jan;24(1):21-34. doi: 10.1016/0022-2828(92)91156-y. PMID: 1564729.
Copy Download .nbib Format: NLM
Share it on

J Mol Cell Cardiol. 1992 Jan;24(1):21-34. doi: 10.1016/0022-2828(92)91156-y.

Protective effect of carteolol, a beta-blocker, on myocardial cellular damage in ischemic and reperfused pig hearts: assessment with gated in vivo 31-phosphorus magnetic resonance spectroscopy and electron microscopy.

Journal of molecular and cellular cardiology

M Ishida, H Fujiwara, M Kida, C Kawai, S Nakayama, S Yamashita, I Miura, Y Yabuuchi

Affiliations

  1. Department of Internal Medicine, Kyoto University, Japan.

PMID: 1564729 DOI: 10.1016/0022-2828(92)91156-y

Abstract

To assess the effect of carteolol, a beta-blocker, on ischemia and reperfusion, changes in the ultrastructure of myocytes and energy metabolism were studied by 31P-NMR in 41 pig hearts without collateral circulation. The left anterior descending coronary artery was occluded for 20 min and reperfused for 120 min in three groups: seven pigs (group 1, no treatment with carteolol; group 2, pre-ischemia treatment with carteolol (10 micrograms/kg); group 3, post-ischemia treatment with carteolol before reperfusion). Other groups of five pigs were killed after 120 min of ischemia (group 4, no treatment; group 5, pre-ischemia treatment) or 20 min of ischemia (group 6, no treatment; group 7, pre-ischemia treatment). After 20 min of ischemia, ATP was higher in groups 2 (76 +/- 9% of the baseline value) than in group 1 (59 +/- 5%) and group 3 (60 +/- 10%). However, the difference disappeared after 30 min of ischemia. After 120 min of reperfusion, ATP showed much better recovery in group 2 (92 +/- 9%) than in groups 1 (66 +/- 7%) and 3 (68 +/- 10%). Ischemic injury, as viewed by light and electron microscopy, was milder in group 7 than in group 6 after 20 min occlusion, but the myocytes were almost normal after 120 min reperfusion in groups 1 to 3. The heart rate, blood pressure and rate pressure product showed no significant difference among the groups. These results indicate that pre-ischemia treatment with carteolol provided protection against ischemic cellular injury and accelerated the repletion of ATP during reperfusion, but the post-ischemia treatment did not lead to recovery of ATP. Therefore, the favorable effect during reperfusion of pre-ischemia treatment with carteolol depends on its protective effect during ischemia.

Similar articles

Substances

MeSH terms

Publication Types