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Kanter M, Coskun O, Budancamanak M. Hepatoprotective effects of Nigella sativa L and Urtica dioica L on lipid peroxidation, antioxidant enzyme systems and liver enzymes in carbon tetrachloride-treated rats. World J Gastroenterol. 2005;11(42):6684-8doi: 10.3748/wjg.v11.i42.6684.
Kanter, M., Coskun, O., & Budancamanak, M. (2005). Hepatoprotective effects of Nigella sativa L and Urtica dioica L on lipid peroxidation, antioxidant enzyme systems and liver enzymes in carbon tetrachloride-treated rats. World journal of gastroenterology, 11(42), 6684-8. https://doi.org/10.3748/wjg.v11.i42.6684
Kanter, Mehmet, et al. "Hepatoprotective effects of Nigella sativa L and Urtica dioica L on lipid peroxidation, antioxidant enzyme systems and liver enzymes in carbon tetrachloride-treated rats." World journal of gastroenterology vol. 11,42 (2005): 6684-8. doi: https://doi.org/10.3748/wjg.v11.i42.6684
Kanter M, Coskun O, Budancamanak M. Hepatoprotective effects of Nigella sativa L and Urtica dioica L on lipid peroxidation, antioxidant enzyme systems and liver enzymes in carbon tetrachloride-treated rats. World J Gastroenterol. 2005 Nov 14;11(42):6684-8. doi: 10.3748/wjg.v11.i42.6684. PMID: 16425366; PMCID: PMC4355766.
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World J Gastroenterol. 2005 Nov 14;11(42):6684-8. doi: 10.3748/wjg.v11.i42.6684.

Hepatoprotective effects of Nigella sativa L and Urtica dioica L on lipid peroxidation, antioxidant enzyme systems and liver enzymes in carbon tetrachloride-treated rats.

World journal of gastroenterology

Mehmet Kanter, Omer Coskun, Mustafa Budancamanak

Affiliations

  1. Department of Histology and Embryology, Faculty of Medicine, Trakya University, Edirne, Turkey. [email protected]

PMID: 16425366 PMCID: PMC4355766 DOI: 10.3748/wjg.v11.i42.6684

Abstract

AIM: To investigate the effects of Nigella sativa L (NS) and Urtica dioica L (UD) on lipid peroxidation, antioxidant enzyme systems and liver enzymes in CCl(4)-treated rats.

METHODS: Fifty-six healthy male Wistar albino rats were used in this study. The rats were randomly allotted into one of the four experimental groups: A (CCl(4)-only treated), B (CCl(4)+UD treated), C (CCl(4)+NS treated) and D (CCl(4)+UD+NS treated), each containing 14 animals. All groups received CCl(4) (0.8 mL/kg of body weight, sc, twice a week for 60 d). In addition, B, C and D groups also received daily i.p. injections of 0.2 mL/kg NS or/and 2 mL/kg UD oils for 60 d. Group A, on the other hand, received only 2 mL/kg normal saline solution for 60 d. Blood samples for the biochemical analysis were taken by cardiac puncture from randomly chosen-seven rats in each treatment group at beginning and on the 60th d of the experiment.

RESULTS: The CCl(4) treatment for 60 d increased the lipid peroxidation and liver enzymes, and also decreased the antioxidant enzyme levels. NS or UD treatment (alone or combination) for 60 d decreased the elevated lipid peroxidation and liver enzyme levels and also increased the reduced antioxidant enzyme levels. The weight of rats decreased in group A, and increased in groups B, C and D.

CONCLUSION: NS and UD decrease the lipid per-oxidation and liver enzymes, and increase the anti-oxidant defense system activity in the CCl4-treated rats.

References

  1. Semin Liver Dis. 1990 Feb;10(1):56-65 - PubMed
  2. Phytother Res. 2003 Sep;17 (8):942-6 - PubMed
  3. Biochim Biophys Acta. 1994 Jul 6;1200(2):93-9 - PubMed
  4. J Lab Clin Med. 1963 May;61:882-8 - PubMed
  5. FEBS Lett. 1999 Jan 8;442(1):89-94 - PubMed
  6. Free Radic Biol Med. 1990;8(3):281-91 - PubMed
  7. Clin Chem. 1964 Dec;10:1078-86 - PubMed
  8. Biochem Biophys Res Commun. 1993 Aug 16;194(3):1044-50 - PubMed
  9. Nihon Juigaku Zasshi. 1990 Dec;52(6):1281-3 - PubMed
  10. Planta Med. 1989 Oct;55(5):452-4 - PubMed
  11. Phytomedicine. 2003;10(5):405-15 - PubMed
  12. Ann Clin Biochem. 1997 Nov;34 ( Pt 6):656-63 - PubMed
  13. Hepatology. 2001 Feb;33(2):483-4 - PubMed
  14. Hepatology. 1992 Aug;16(2):448-53 - PubMed
  15. J Vet Med A Physiol Pathol Clin Med. 2003 Jun;50(5):264-8 - PubMed
  16. J Pharm Belg. 1998 Mar-Apr;53(2):87-93; discussion 93-5 - PubMed
  17. Drug Metab Rev. 1989;20(2-4):275-84 - PubMed
  18. Endeavour. 1984;8(2):65-70 - PubMed
  19. Rom J Intern Med. 1995 Jan-Jun;33(1-2):113-20 - PubMed
  20. Immunopharmacology. 1995 Aug;30(2):147-55 - PubMed
  21. Hepatology. 1990 Jan;11(1):127-37 - PubMed
  22. Dig Dis Sci. 1991 Jun;36(6):770-4 - PubMed
  23. Planta Med. 2000 Feb;66(1):44-7 - PubMed
  24. Dtsch Tierarztl Wochenschr. 2001 Feb;108(2):71-3 - PubMed
  25. Clin Chem. 1970 Nov;16(11):903-10 - PubMed
  26. Free Radic Biol Med. 1996;20(3):351-9 - PubMed
  27. Hepatology. 1992 Oct;16(4):1014-21 - PubMed
  28. Methods Enzymol. 1990;186:421-31 - PubMed
  29. Fundam Clin Pharmacol. 1989;3(3):183-91 - PubMed
  30. J Gastroenterol Hepatol. 2000 Mar;15 Suppl:D84-90 - PubMed
  31. G Clin Med. 1970 Oct;51(10 ):753-9 - PubMed
  32. Toxicol Lett. 1998 Mar 16;95(1):23-9 - PubMed
  33. Toxicology. 2003 May 1;187(1):67-73 - PubMed
  34. Biochem Pharmacol. 1998 Sep 15;56(6):773-9 - PubMed
  35. Zhongguo Yao Li Xue Bao. 1997 Sep;18(5):478-80 - PubMed
  36. Gen Pharmacol. 1993 Sep;24(5):1115-22 - PubMed
  37. Methods Enzymol. 1979;62:3-11 - PubMed
  38. Planta Med. 1995 Feb;61(1):33-6 - PubMed

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