Display options
Cite
Rutlen DL, Welt FG, Ilebekk A. Passive effect of reduced cardiac function on splanchnic intravascular volume. Am J Physiol. 1992;262(5):H1361-4doi: 10.1152/ajpheart.1992.262.5.H1361.
Rutlen, D. L., Welt, F. G., & Ilebekk, A. (1992). Passive effect of reduced cardiac function on splanchnic intravascular volume. The American journal of physiology, 262(5), H1361-4. https://doi.org/10.1152/ajpheart.1992.262.5.H1361
Rutlen, D L, et al. "Passive effect of reduced cardiac function on splanchnic intravascular volume." The American journal of physiology vol. 262,5 (1992): H1361-4. doi: https://doi.org/10.1152/ajpheart.1992.262.5.H1361
Rutlen DL, Welt FG, Ilebekk A. Passive effect of reduced cardiac function on splanchnic intravascular volume. Am J Physiol. 1992 May;262(5):H1361-4. doi: 10.1152/ajpheart.1992.262.5.H1361. PMID: 1590439.
Copy Download .nbib Format: NLM
Share it on
Full text links
Atypon

Am J Physiol. 1992 May;262(5):H1361-4. doi: 10.1152/ajpheart.1992.262.5.H1361.

Passive effect of reduced cardiac function on splanchnic intravascular volume.

The American journal of physiology

D L Rutlen, F G Welt, A Ilebekk

Affiliations

  1. Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06510.

PMID: 1590439 DOI: 10.1152/ajpheart.1992.262.5.H1361

Abstract

It has been hypothesized that lowered cardiac output due to heart failure results in passive redistribution of intravascular volume from the peripheral circulation to the central circulation and that this redistribution acts to support cardiac output. To test this hypothesis, acute heart failure was induced by rapid atrial pacing to raise heart rate from 148 +/- 6 to 232 +/- 1 beats/min for 5 min, while splanchnic intravascular volume was assessed with radionuclide imaging in eight anesthetized pigs that had undergone prior carotid denervation and vagotomy. Cardiac output decreased from 3,350 +/- 410 to 2,170 +/- 290 ml/min (P less than 0.001), mean arterial pressure decreased from 103 +/- 5 to 84 +/- 4 mmHg (P less than 0.001), left atrial pressure increased from 5.9 +/- 0.6 to 10.8 +/- 0.9 mmHg (P less than 0.001), right atrial pressure increased from 2.4 +/- 0.5 to 4.8 +/- 0.9 mmHg (P less than 0.001), total splanchnic intravascular volume did not change (0 +/- 2 ml), splenic intravascular volume decreased 11 +/- 3% (P less than 0.001), hepatic intravascular volume increased 12 +/- 2% (P less than 0.001), and mesenteric intravascular volume did not change (-3 +/- 2%). Thus, when cardiac output is lowered with pacing-induced acute heart failure, lowered perfusion pressure acts to lower splenic intravascular volume and increased central venous pressure acts to increase hepatic intravascular volume; however, total splanchnic intravascular volume does not decrease to support cardiac filling and cardiac output.

Similar articles

Show all 13 similar articles

MeSH terms

Publication Types

Grant support

LinkOut - more resources