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Nelson S, Steward RH, Traber L, et al. Endotoxin-induced alterations in contractility of isolated blood vessels from sheep. Am J Physiol. 1991;260(6):H1790-4doi: 10.1152/ajpheart.1991.260.6.H1790.
Nelson, S., Steward, R. H., Traber, L., & Traber, D. (1991). Endotoxin-induced alterations in contractility of isolated blood vessels from sheep. The American journal of physiology, 260(6), H1790-4. https://doi.org/10.1152/ajpheart.1991.260.6.H1790
Nelson, S, et al. "Endotoxin-induced alterations in contractility of isolated blood vessels from sheep." The American journal of physiology vol. 260,6 (1991): H1790-4. doi: https://doi.org/10.1152/ajpheart.1991.260.6.H1790
Nelson S, Steward RH, Traber L, Traber D. Endotoxin-induced alterations in contractility of isolated blood vessels from sheep. Am J Physiol. 1991 Jun;260(6):H1790-4. doi: 10.1152/ajpheart.1991.260.6.H1790. PMID: 1647694.
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Am J Physiol. 1991 Jun;260(6):H1790-4. doi: 10.1152/ajpheart.1991.260.6.H1790.

Endotoxin-induced alterations in contractility of isolated blood vessels from sheep.

The American journal of physiology

S Nelson, R H Steward, L Traber, D Traber

Affiliations

  1. Department of Anesthesiology, University of Texas Medical Branch, Galveston 77550.

PMID: 1647694 DOI: 10.1152/ajpheart.1991.260.6.H1790

Abstract

The present study examined reactivity to norepinephrine (NE) and KCl in isolated, suffused blood vessels from the systemic and pulmonary circulations of endotoxin-treated and control sheep. A possible mechanism underlying an endotoxin-induced alteration in vascular reactivity was also investigated. Chronically instrumented sheep were given Escherichia coli endotoxin (1.5 micrograms/kg). Eight to 12 h later these endotoxin-treated animals exhibited a significantly increased cardiac output and decreased systemic vascular pressure and resistance. The pulmonary vascular pressure and resistance were not changed. The isolated superficial femoral artery from the endotoxin sheep exhibited depressed contractions in response to KCl (75 mM) and to NE (10(-7)-10(-5) M), whereas the pulmonary artery (tertiary branch) did not exhibit altered reactivity. The decreased sensitivity to NE in the femoral artery from endotoxin sheep did not appear to involve an alteration of alpha- or beta-adrenoceptors, or an increased release of vasodilator prostanoids, or endothelium-derived relaxing factor.

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