Display options
Cite
Sawaishi Y, Komatsu K, Takeda O, et al. A case of tubulo-interstitial nephritis with exfoliative dermatitis and hepatitis due to phenobarbital hypersensitivity. Eur J Pediatr. 1992;151(1):69-72doi: 10.1007/BF02073898.
Sawaishi, Y., Komatsu, K., Takeda, O., Tazawa, Y., Takahashi, I., Hayasaka, K., & Takada, G. (1992). A case of tubulo-interstitial nephritis with exfoliative dermatitis and hepatitis due to phenobarbital hypersensitivity. European journal of pediatrics, 151(1), 69-72. https://doi.org/10.1007/BF02073898
Sawaishi, Y, et al. "A case of tubulo-interstitial nephritis with exfoliative dermatitis and hepatitis due to phenobarbital hypersensitivity." European journal of pediatrics vol. 151,1 (1992): 69-72. doi: https://doi.org/10.1007/BF02073898
Sawaishi Y, Komatsu K, Takeda O, Tazawa Y, Takahashi I, Hayasaka K, Takada G. A case of tubulo-interstitial nephritis with exfoliative dermatitis and hepatitis due to phenobarbital hypersensitivity. Eur J Pediatr. 1992 Jan;151(1):69-72. doi: 10.1007/BF02073898. PMID: 1530819.
Copy Download .nbib Format: NLM
Share it on

Eur J Pediatr. 1992 Jan;151(1):69-72. doi: 10.1007/BF02073898.

A case of tubulo-interstitial nephritis with exfoliative dermatitis and hepatitis due to phenobarbital hypersensitivity.

European journal of pediatrics

Y Sawaishi, K Komatsu, O Takeda, Y Tazawa, I Takahashi, K Hayasaka, G Takada

Affiliations

  1. Department of Paediatrics, Akita University School of Medicine, Japan.

PMID: 1530819 DOI: 10.1007/BF02073898

Abstract

Severe exfoliative dermatitis and liver dysfunction developed in a 5-year-old girl 3 weeks after initiation of phenobarbital therapy. Liver function improved gradually after discontinuation of phenobarbital. During the convalescent stage an initially mild renal dysfunction was exacerbated by episodes of post-transfusion haemolysis. Liver biopsy revealed moderate parenchymal damage with subacute cellular infiltration. Renal biopsy demonstrated the cardinal findings of interstitial nephritis, excluding the possibility of acute tubular necrosis caused by haemolysis. Serial lymphocyte transformation studies and skin patch tests gave positive results for phenobarbital, supporting the view that these were unusual complications of phenobarbital hypersensitivity.

Similar articles

Cited by

References

  1. Clin Exp Immunol. 1977 Aug;29(2):272-7 - PubMed
  2. Am J Gastroenterol. 1980 Sep;74(3):270-3 - PubMed
  3. J Pediatr. 1978 Jun;92(6):915-20 - PubMed
  4. Br Med J. 1972 Nov 25;4(5838):490 - PubMed
  5. J Pediatr. 1977 Sep;91(3):438-41 - PubMed
  6. Lancet. 1974 Sep 21;2(7882):718 - PubMed
  7. J Pediatr. 1981 May;98(5):830-2 - PubMed
  8. South Med J. 1984 Jan;77(1):94 - PubMed
  9. N Engl J Med. 1968 Dec 5;279(23):1245-52 - PubMed
  10. Am J Med. 1953 May;14(5):600-4 - PubMed
  11. Ann Intern Med. 1980 Nov;93(5):735-41 - PubMed

Substances

MeSH terms

Publication Types

LinkOut - more resources