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Bioorg Med Chem Lett. 2005 Nov 01;15(21):4699-702. doi: 10.1016/j.bmcl.2005.07.065.

Synthesis of 4-(5-[18F]fluoromethyl-3-phenylisoxazol-4-yl)benzenesulfonamide, a new [18F]fluorinated analogue of valdecoxib, as a potential radiotracer for imaging cyclooxygenase-2 with positron emission tomography.

Bioorganic & medicinal chemistry letters

Tatsushi Toyokuni, J S Dileep Kumar, Joseph C Walsh, Alan Shapiro, John J Talley, Michael E Phelps, Harvey R Herschman, Jorge R Barrio, Nagichettiar Satyamurthy

Affiliations

  1. Crump Institute for Molecular Imaging and LA Tech Center, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA. [email protected]

PMID: 16153836 DOI: 10.1016/j.bmcl.2005.07.065

Abstract

Fluoroalkyl and fluoroaryl analogues of valdecoxib were found to possess potent inhibitory activities against cyclooxygenase-2 comparable to that of the parent valdecoxib. Among them, the fluoromethyl analogue was chosen for 18F-labeling. Thus, 4-(5-[18F]fluoromethyl-3-phenylisoxazol-4-yl)benzenesulfonamide (approximately 2000 Ci/mmol at end of synthesis) was synthesized by [18F]fluoride-ion displacement of the corresponding tosylate in approximately 40% decay-corrected radiochemical yield within approximately 120 min from end of bombardment.

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