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Gan To Kagaku Ryoho. 1992 Aug;19(10):1671-4.

[Targeting cancer chemotherapy using temperature-sensitive liposomes containing adriamycin conjugated with monoclonal antibodies].

Gan to kagaku ryoho. Cancer & chemotherapy

[Article in Japanese]
S Shibata, K Kumai, T Takahashi, Y Murayama, K Ishibiki, M Kitajima

Affiliations

  1. Dept. of Surgery, School of Medicine, Keio University.

PMID: 1530328

Abstract

Liposomes have a specific liquid-crystalline phase transition temperature (Tc), at which they release an entrapped drug. Temperature-sensitive liposomes containing adriamycin (TS-Lip-ADM) were made of dipalmitoylphosphatidylcholine (DPPC, Tc: 41 degrees C), distearoylphosphatidylcholine (DSPC, Tc: 54 degrees C), cholesterol and adriamycin. Monoclonal antibodies against human alpha-fetoprotein (AFP) were conjugated to TS-Lip-ADM. When liposomal suspension was immersed in a bath, the release rate of ADM from TS-Lip-ADM = Ab increased, as the temperature increased from 34 degrees C to 42 degrees C. ADM release was dependent on the temperature.

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