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Lakatta EG. Excitation-contraction coupling in heart failure. Hosp Pract (Off Ed). 1991;26(7):85-8, 91-8doi: 10.1080/21548331.1991.11704209.
Lakatta, E. G. (1991). Excitation-contraction coupling in heart failure. Hospital practice (Office ed.), 26(7), 85-8, 91-8. https://doi.org/10.1080/21548331.1991.11704209
Lakatta, E G. "Excitation-contraction coupling in heart failure." Hospital practice (Office ed.) vol. 26,7 (1991): 85-8, 91-8. doi: https://doi.org/10.1080/21548331.1991.11704209
Lakatta EG. Excitation-contraction coupling in heart failure. Hosp Pract (Off Ed). 1991 Jul 15;26(7):85-8, 91-8. doi: 10.1080/21548331.1991.11704209. PMID: 1677009.
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Hosp Pract (Off Ed). 1991 Jul 15;26(7):85-8, 91-8. doi: 10.1080/21548331.1991.11704209.

Excitation-contraction coupling in heart failure.

Hospital practice (Office ed.)

E G Lakatta

Affiliations

  1. Laboratory of Cardiovascular Science, National Institute on Aging, Baltimore.

PMID: 1677009 DOI: 10.1080/21548331.1991.11704209

Abstract

A central feature of the excitation-contraction cycle-myocardial Ca2+ handling--is altered in humans with cardiomyopathy. Many adaptive changes in excitation-contraction mechanisms observed in aged or hypertensive animals also supervene in the failing human heart. Heart failure may thus emerge when such changes lead to systolic or diastolic insufficiency.

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