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Vaage-Nilsen M, Rasmussen V, Holländer NH, et al. Prevalence of transient myocardial ischaemia during the first year after a myocardial infarction. Effect of treatment with verapamil. The Danish Study Group on Verapamil in Myocardial Infarction. Eur Heart J. 1992;13(5):666-70doi: 10.1093/oxfordjournals.eurheartj.a060233.
Vaage-Nilsen, M., Rasmussen, V., Holländer, N. H., & Hansen, J. F. (1992). Prevalence of transient myocardial ischaemia during the first year after a myocardial infarction. Effect of treatment with verapamil. The Danish Study Group on Verapamil in Myocardial Infarction. European heart journal, 13(5), 666-70. https://doi.org/10.1093/oxfordjournals.eurheartj.a060233
Vaage-Nilsen, M, et al. "Prevalence of transient myocardial ischaemia during the first year after a myocardial infarction. Effect of treatment with verapamil. The Danish Study Group on Verapamil in Myocardial Infarction." European heart journal vol. 13,5 (1992): 666-70. doi: https://doi.org/10.1093/oxfordjournals.eurheartj.a060233
Vaage-Nilsen M, Rasmussen V, Holländer NH, Hansen JF. Prevalence of transient myocardial ischaemia during the first year after a myocardial infarction. Effect of treatment with verapamil. The Danish Study Group on Verapamil in Myocardial Infarction. Eur Heart J. 1992 May;13(5):666-70. doi: 10.1093/oxfordjournals.eurheartj.a060233. PMID: 1618211.
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Eur Heart J. 1992 May;13(5):666-70. doi: 10.1093/oxfordjournals.eurheartj.a060233.

Prevalence of transient myocardial ischaemia during the first year after a myocardial infarction. Effect of treatment with verapamil. The Danish Study Group on Verapamil in Myocardial Infarction.

European heart journal

M Vaage-Nilsen, V Rasmussen, N H Holländer, J F Hansen

Affiliations

  1. Holter Laboratory, Hvidovre University Hospital, Denmark.

PMID: 1618211 DOI: 10.1093/oxfordjournals.eurheartj.a060233

Abstract

DAVIT-II is a double-blind, randomized, multicentre, placebo-controlled study of long-term treatment with verapamil 360 mg per day administered to patients who have suffered an acute myocardial infarction (AMI). In the present study, comprising a subset of DAVIT-II, 48 h continuous ECG recordings demonstrated transient ST segment deviation indicative of myocardial ischaemia after one week, prior to randomization, in 18% (10 of 57) of the patients. After one month, 24% (11 of 46) of the placebo and 8% (3 of 39) of the verapamil-treated patients (P = 0.04) had myocardial ischaemia; after one year the figures were 26% (9 of 35) and 4% (1 of 27) (P = 0.02), respectively. At 18 months the 'major' event rate in patients who had had ischaemia before randomization was 40% and 23.8% in patients without ischaemia (P = 0.057). In the placebo group, 63% of 91 episodes of ST depression were recorded between 0600 h and 1800 h, and 62% of 26 episodes of ST elevation between 1800 h and 0600 h (P less than 0.001). Nine episodes of ST depression and no episode of ST elevation were recorded in the verapamil-treated patients. In conclusion, 20-25% of post-AMI patients have transient ischaemia; verapamil prevents ischaemia, and a pronounced circadian variation of ST segment deviations can be demonstrated.

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