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Ehlhardt WJ, Howbert JJ. Metabolism and disposition of p-chloroaniline in rat, mouse, and monkey. Drug Metab Dispos. 1991;19(2):366-9
Ehlhardt, W. J., & Howbert, J. J. (1991). Metabolism and disposition of p-chloroaniline in rat, mouse, and monkey. Drug metabolism and disposition: the biological fate of chemicals, 19(2), 366-9.
Ehlhardt, W J, and Howbert, J J. "Metabolism and disposition of p-chloroaniline in rat, mouse, and monkey." Drug metabolism and disposition: the biological fate of chemicals vol. 19,2 (1991): 366-9.
Ehlhardt WJ, Howbert JJ. Metabolism and disposition of p-chloroaniline in rat, mouse, and monkey. Drug Metab Dispos. 1991 Mar-Apr;19(2):366-9. PMID: 1676638.
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Drug Metab Dispos. 1991 Mar-Apr;19(2):366-9.

Metabolism and disposition of p-chloroaniline in rat, mouse, and monkey.

Drug metabolism and disposition: the biological fate of chemicals

W J Ehlhardt, J J Howbert

Affiliations

  1. Department of Drug Metabolism, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285.

PMID: 1676638

Abstract

The metabolism and disposition of [14C]p-chloroaniline was studied in the male Fisher 344 rat, female C3H mouse, and male rhesus monkey. Greater than 90% of the radiocarbon is eliminated through the urine in all species. A major route of metabolism is orthohydroxylation, whereby 2-amino-5-chlorophenyl sulfate is the major excretion product in all species. Excretion of p-chloro-oxanilic acid and p-chloroglycolanilide, oxidation products of p-chloroacetanilide, is significant in the rat. The appearance of p-chloroacetanilide along with p-chloroaniline in plasma after an oral dose of [14C]p-chloroaniline also was studied in rhesus monkey. In addition to p-chloroacetanilide, 2-amino-5-chlorophenyl sulfate is found to be a major circulating metabolite.

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