Display options
Cite
Schmid PA, Burger HR, Spycher MA, et al. Primäre Amyloidose der Leber. [Primary amyloidosis of the liver]. Dtsch Med Wochenschr. 1992;117(26):1014-8doi: 10.1055/s-2008-1062404.
Schmid, P. A., Burger, H. R., Spycher, M. A., Bühler, H., & Heitz, P. U. (1992). Primäre Amyloidose der Leber. [Primary amyloidosis of the liver]. Deutsche medizinische Wochenschrift (1946), 117(26), 1014-8. https://doi.org/10.1055/s-2008-1062404
Schmid, P A, et al. "Primäre Amyloidose der Leber." [Primary amyloidosis of the liver]. Deutsche medizinische Wochenschrift (1946) vol. 117,26 (1992): 1014-8. doi: https://doi.org/10.1055/s-2008-1062404
Schmid PA, Burger HR, Spycher MA, Bühler H, Heitz PU. Primäre Amyloidose der Leber. [Primary amyloidosis of the liver]. Dtsch Med Wochenschr. 1992 Jun 26;117(26):1014-8. doi: 10.1055/s-2008-1062404. German. PMID: 1618110.
Copy Download .nbib Format: NLM
Share it on
Full text links
Georg Thieme Verlag Stuttgart, New York

Dtsch Med Wochenschr. 1992 Jun 26;117(26):1014-8. doi: 10.1055/s-2008-1062404.

[Primary amyloidosis of the liver].

Deutsche medizinische Wochenschrift (1946)

[Article in German]
P A Schmid, H R Burger, M A Spycher, H Bühler, P U Heitz

Affiliations

  1. Medizinische Klinik, Stadtspital Waid.

PMID: 1618110 DOI: 10.1055/s-2008-1062404

Abstract

For 2 years a 72-year-old man had suffered from nonspecific upper abdominal discomfort and hepatomegaly. The gamma-glutamate transaminase concentration was increased to 121 U/l, the erythrocyte sedimentation rate was 80 mm in the first hour. Histological examination of tissue from the enlarged liver (22 cm in the midclavicular line) revealed the diagnosis of amyloidosis. The gastric mucosa, duodenum and rectum were not involved. Two years later ascites developed; six months after this he was again hospitalized in hepatic coma. Now, for the first time, a type IgA-lambda paraprotein was demonstrated by serum immunoelectrophoresis. The patient died of slowly progressing anicteric liver failure after having been ill for a total of 4 1/2 years. At autopsy there were extensive amyloid deposits throughout the liver and spleen so that the structure of these organs was hardly recognizable. The amyloid deposits in the liver were restricted to the glomerular region, while there was no amyloid in the heart. Histochemical tests showed that the deposits were strongly positive to the anti-lambda antibody. This was thus a case of primary (AL-lambda) amyloidosis of the liver and spleen which had taken an unusually prolonged course, because the heart was not involved at all and the kidneys only slightly.

Similar articles

Show all 9 similar articles

Cited by

Substances

MeSH terms

Publication Types

LinkOut - more resources