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Gaertner DJ, Jacoby RO, Paturzo FX, et al. Modulation of lethal and persistent rat parvovirus infection by antibody. Arch Virol. 1991;118(1):1-9doi: 10.1007/BF01311299.
Gaertner, D. J., Jacoby, R. O., Paturzo, F. X., Johnson, E. A., Brandsma, J. L., & Smith, A. L. (1991). Modulation of lethal and persistent rat parvovirus infection by antibody. Archives of virology, 118(1), 1-9. https://doi.org/10.1007/BF01311299
Gaertner, D J, et al. "Modulation of lethal and persistent rat parvovirus infection by antibody." Archives of virology vol. 118,1 (1991): 1-9. doi: https://doi.org/10.1007/BF01311299
Gaertner DJ, Jacoby RO, Paturzo FX, Johnson EA, Brandsma JL, Smith AL. Modulation of lethal and persistent rat parvovirus infection by antibody. Arch Virol. 1991;118(1):1-9. doi: 10.1007/BF01311299. PMID: 1646590; PMCID: PMC7086996.
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Arch Virol. 1991;118(1):1-9. doi: 10.1007/BF01311299.

Modulation of lethal and persistent rat parvovirus infection by antibody.

Archives of virology

D J Gaertner, R O Jacoby, F X Paturzo, E A Johnson, J L Brandsma, A L Smith

Affiliations

  1. Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut.

PMID: 1646590 PMCID: PMC7086996 DOI: 10.1007/BF01311299
Free PMC Article

Abstract

Two day-old athymic (rnu/rnu) and euthymic (rnu/+) rat pups nursing immune or non-immune dams were inoculated oronasally with the Yale strain of rat virus (RV-Y). All athymic and euthymic pups (57/57) from immune dams remained clinically normal, whereas 51 of 66 athymic and euthymic pups from non-immune dams died within 30 days. Infectious RV was detected by explant culture in 12 of 15 surviving pups of both genotypes from non-immune dams 30 days after inoculation, but in none of the 57 surviving pups from immune dams. RV-Y DNA was detected by Southern blotting in kidneys of surviving athymic pups from non-immune dams but was not detected in pups from immune dams. Euthymic pups from immune dams appeared not to produce endogenous antibody to RV after virus challenge, whereas euthymic pups from non-immune dams produced high-titered RV immune serum. Pups of both genotypes given immune serum prior to or with RV were fully protected from disease and persistent infection, whereas pups given immune serum 24 hours after RV were partially protected. These studies show that RV antibody offers significant protection against lethal and persistent RV infection.

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