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Yamada S, Ishii E, Nakagawara A, et al. Features and outcome of advanced neuroblastoma with distant lymph node metastasis. Pediatr Hematol Oncol. 1992;9(1):49-56doi: 10.3109/08880019209006396.
Yamada, S., Ishii, E., Nakagawara, A., Akazawa, K., Tasaka, H., Kajiwara, M., Kawakami, K., & Ueda, K. (1992). Features and outcome of advanced neuroblastoma with distant lymph node metastasis. Pediatric hematology and oncology, 9(1), 49-56. https://doi.org/10.3109/08880019209006396
Yamada, S, et al. "Features and outcome of advanced neuroblastoma with distant lymph node metastasis." Pediatric hematology and oncology vol. 9,1 (1992): 49-56. doi: https://doi.org/10.3109/08880019209006396
Yamada S, Ishii E, Nakagawara A, Akazawa K, Tasaka H, Kajiwara M, Kawakami K, Ueda K. Features and outcome of advanced neuroblastoma with distant lymph node metastasis. Pediatr Hematol Oncol. 1992 Jan-Mar;9(1):49-56. doi: 10.3109/08880019209006396. PMID: 1558776.
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Pediatr Hematol Oncol. 1992 Jan-Mar;9(1):49-56. doi: 10.3109/08880019209006396.

Features and outcome of advanced neuroblastoma with distant lymph node metastasis.

Pediatric hematology and oncology

S Yamada, E Ishii, A Nakagawara, K Akazawa, H Tasaka, M Kajiwara, K Kawakami, K Ueda

Affiliations

  1. Department of Pediatrics, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

PMID: 1558776 DOI: 10.3109/08880019209006396

Abstract

We examined 52 children with advanced neuroblastoma who were diagnosed and treated during the past 7 years, and investigated the correlation between the degree of lymph node (LN) metastasis and the prognosis of neuroblastoma. In 8 of the 52 patients, distant LN metastasis was confirmed both radiographically and histologically. The urinary homovanillic acid (HVA) level was markedly elevated in these patients, and it was higher than that in patients with regional LN metastasis (p less than .05). The urinary vanillylmandelic acid (VMA) level and the VMA/HVA ratio were not significantly different between patients with regional and distant LN metastasis. None of the four examined patients with distant LN metastasis showed N-myc amplification of neuroblastoma tumors. An analysis of the survival rate in each patient group classified according to the degree of LN metastasis showed that the prognosis of the patients without LN metastasis or with distant LN metastasis tended to be better than that of patients with regional LN metastasis. Our results indicate that patients with distant LN metastasis may belong to a subclass with different biological features and a better prognosis than those of other groups.

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