Display options
Cite
Cosín J, Rivera M, Solaz J, et al. Effects of captopril on regional segment motion during acute coronary occlusion. Clin Cardiol. 1992;15(6):411-6doi: 10.1002/clc.4960150604.
Cosín, J., Rivera, M., Solaz, J., Hernándiz, A., & Andrés, F. (1992). Effects of captopril on regional segment motion during acute coronary occlusion. Clinical cardiology, 15(6), 411-6. https://doi.org/10.1002/clc.4960150604
Cosín, J, et al. "Effects of captopril on regional segment motion during acute coronary occlusion." Clinical cardiology vol. 15,6 (1992): 411-6. doi: https://doi.org/10.1002/clc.4960150604
Cosín J, Rivera M, Solaz J, Hernándiz A, Andrés F. Effects of captopril on regional segment motion during acute coronary occlusion. Clin Cardiol. 1992 Jun;15(6):411-6. doi: 10.1002/clc.4960150604. PMID: 1617821.
Copy Download .nbib Format: NLM
Share it on
Full text links
Wiley

Clin Cardiol. 1992 Jun;15(6):411-6. doi: 10.1002/clc.4960150604.

Effects of captopril on regional segment motion during acute coronary occlusion.

Clinical cardiology

J Cosín, M Rivera, J Solaz, A Hernándiz, F Andrés

Affiliations

  1. Cardiocirculatory Research Unit, La Fe Hospital, Valencia, Spain.

PMID: 1617821 DOI: 10.1002/clc.4960150604
Free Article

Abstract

The effects of captopril on myocardial segment function in different degrees of transient coronary occlusion were studied using ultrasonic dimension gauges in 15 open-chest dogs. The occlusion procedures (OP) were performed on the left anterior descending coronary artery (LAD) in eight dogs and on the left circumflex coronary artery (Cx) in seven dogs. To measure the changes in segment shortening in the subendocardium we used eight dogs (ischemic and control zones: four dogs LAD and four dogs Cx). To measure the changes in wall thickening we used seven dogs (ischemic and control zones: three dogs LAD and four dogs Cx). Total coronary OP lasting 1 min and partial OP (70-80%) lasting 1 min and 2 min 30 s, before and after captopril (0.25 mg/kg i.v.) were performed. Left ventricular pressure, dP/dt, coronary flow, and ECG were monitored. Total coronary OP (1 min) changed segment shortening (18% LAD; 14% Cx) and wall thickening (19% LAD; 18% Cx) to values of dyskinesis (-3% and -4% for shortening; -6% and -5% for thickening). Captopril improved regional function maintaining positive values for shortening (4% LAD; 3% Cx) and thickening (0.3% LAD; 4% Cx). Similar responses were obtained during partial OP and captopril. Results suggest that captopril produced a significant improvement in the regional function parameters affected by ischemia both in total and partial obstructions.

Substances

MeSH terms

Publication Types

LinkOut - more resources