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Brown L, Espinosa R, Le Beau MM, et al. HEN1 and HEN2: a subgroup of basic helix-loop-helix genes that are coexpressed in a human neuroblastoma. Proc Natl Acad Sci U S A. 1992;89(18):8492-6doi: 10.1073/pnas.89.18.8492.
Brown, L., Espinosa, R., Le Beau, M. M., Siciliano, M. J., & Baer, R. (1992). HEN1 and HEN2: a subgroup of basic helix-loop-helix genes that are coexpressed in a human neuroblastoma. Proceedings of the National Academy of Sciences of the United States of America, 89(18), 8492-6. https://doi.org/10.1073/pnas.89.18.8492
Brown, L, et al. "HEN1 and HEN2: a subgroup of basic helix-loop-helix genes that are coexpressed in a human neuroblastoma." Proceedings of the National Academy of Sciences of the United States of America vol. 89,18 (1992): 8492-6. doi: https://doi.org/10.1073/pnas.89.18.8492
Brown L, Espinosa R, Le Beau MM, Siciliano MJ, Baer R. HEN1 and HEN2: a subgroup of basic helix-loop-helix genes that are coexpressed in a human neuroblastoma. Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8492-6. doi: 10.1073/pnas.89.18.8492. PMID: 1528853; PMCID: PMC49946.
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Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8492-6. doi: 10.1073/pnas.89.18.8492.

HEN1 and HEN2: a subgroup of basic helix-loop-helix genes that are coexpressed in a human neuroblastoma.

Proceedings of the National Academy of Sciences of the United States of America

L Brown, R Espinosa, M M Le Beau, M J Siciliano, R Baer

Affiliations

  1. Department of Microbiology, University of Texas Southwestern Medical Center, Dallas 75235.

PMID: 1528853 PMCID: PMC49946 DOI: 10.1073/pnas.89.18.8492
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Abstract

An important family of regulatory molecules is made up of proteins that possess the DNA-binding and dimerization motif known as the basic helix-loop-helix (bHLH) domain. The bHLH family includes subgroups of closely related proteins that share common functional properties and overlapping patterns of expression (e.g., the MyoD1 and achaete-scute subgroups). In this report we describe HEN1 and HEN2, mammalian genes that encode a distinct subgroup of bHLH proteins. The HEN1 gene was identified on the basis of cross-hybridization with TAL1, a known bHLH gene implicated in T-cell acute lymphoblastic leukemia. In situ fluorescence hybridization was used to localize the human HEN1 gene to chromosome band 1q22. HEN1 and HEN2 are coexpressed in the IMR-32 human neuroblastoma cell line, and they encode highly related proteins of 133 and 135 residues, respectively, that share 98% amino acid identity in their hHLH domains. These data imply that the bHLH protein subgroup encoded by HEN1 and HEN2 may serve important regulatory functions in the developing nervous system.

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