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Fuentes DE, Navarro CA, Tantaleán JC, et al. The product of the qacC gene of Staphylococcus epidermidis CH mediates resistance to beta-lactam antibiotics in gram-positive and gram-negative bacteria. Res Microbiol. 2005;156(4):472-7doi: 10.1016/j.resmic.2005.01.002.
Fuentes, D. E., Navarro, C. A., Tantaleán, J. C., Araya, M. A., Saavedra, C. P., Pérez, J. M., Calderón, I. L., Youderian, P. A., Mora, G. C., & Vásquez, C. C. (2005). The product of the qacC gene of Staphylococcus epidermidis CH mediates resistance to beta-lactam antibiotics in gram-positive and gram-negative bacteria. Research in microbiology, 156(4), 472-7. https://doi.org/10.1016/j.resmic.2005.01.002
Fuentes, Derie E, et al. "The product of the qacC gene of Staphylococcus epidermidis CH mediates resistance to beta-lactam antibiotics in gram-positive and gram-negative bacteria." Research in microbiology vol. 156,4 (2005): 472-7. doi: https://doi.org/10.1016/j.resmic.2005.01.002
Fuentes DE, Navarro CA, Tantaleán JC, Araya MA, Saavedra CP, Pérez JM, Calderón IL, Youderian PA, Mora GC, Vásquez CC. The product of the qacC gene of Staphylococcus epidermidis CH mediates resistance to beta-lactam antibiotics in gram-positive and gram-negative bacteria. Res Microbiol. 2005 May;156(4):472-7. doi: 10.1016/j.resmic.2005.01.002. Epub 2005 Feb 19. PMID: 15862444.
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Res Microbiol. 2005 May;156(4):472-7. doi: 10.1016/j.resmic.2005.01.002. Epub 2005 Feb 19.

The product of the qacC gene of Staphylococcus epidermidis CH mediates resistance to beta-lactam antibiotics in gram-positive and gram-negative bacteria.

Research in microbiology

Derie E Fuentes, Claudio A Navarro, Juan C Tantaleán, Manuel A Araya, Claudia P Saavedra, José M Pérez, Iván L Calderón, Phil A Youderian, Guido C Mora, Claudio C Vásquez

Affiliations

  1. Laboratorio de Microbiología Molecular, Departamento de Ciencias Biológicas, Facultad de Química y Biología, Universidad de Santiago de Chile, Casilla 40, Correo 33, Santiago, Chile.

PMID: 15862444 DOI: 10.1016/j.resmic.2005.01.002

Abstract

We have characterized a natural isolate of Staphylococcus epidermidis resistant to heavy metals that carries a small 2391-bp plasmid, pSepCH, encoding the qacC gene. The S. epidermidis qacC gene confers resistance to a number of beta-lactam antibiotics and to ethidium bromide in its natural host and in Escherichia coli K12 and Salmonella enterica sv. Typhimurium. This is the first communication of a small multidrug resistance (SMR) pump involved in resistance to beta-lactam antibiotics. Experiments using tolC, ompW and ompD mutant strains of S. Typhimurium demonstrated that the beta-lactam antibiotic resistance conferred by this pump does not depend on these outer membrane proteins.

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