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Richter-Levin G, Segal M, Sara S. An alpha 2 antagonist, idazoxan, enhances EPSP-spike coupling in the rat dentate gyrus. Brain Res. 1991;540(1):291-4doi: 10.1016/0006-8993(91)90521-v.
Richter-Levin, G., Segal, M., & Sara, S. (1991). An alpha 2 antagonist, idazoxan, enhances EPSP-spike coupling in the rat dentate gyrus. Brain research, 540(1), 291-4. https://doi.org/10.1016/0006-8993(91)90521-v
Richter-Levin, G, et al. "An alpha 2 antagonist, idazoxan, enhances EPSP-spike coupling in the rat dentate gyrus." Brain research vol. 540,1 (1991): 291-4. doi: https://doi.org/10.1016/0006-8993(91)90521-v
Richter-Levin G, Segal M, Sara S. An alpha 2 antagonist, idazoxan, enhances EPSP-spike coupling in the rat dentate gyrus. Brain Res. 1991 Feb 01;540(1):291-4. doi: 10.1016/0006-8993(91)90521-v. PMID: 1675916.
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Elsevier Science

Brain Res. 1991 Feb 01;540(1):291-4. doi: 10.1016/0006-8993(91)90521-v.

An alpha 2 antagonist, idazoxan, enhances EPSP-spike coupling in the rat dentate gyrus.

Brain research

G Richter-Levin, M Segal, S Sara

Affiliations

  1. Center for Neuroscience, Weizmann Institute, Rehovot, Israel.

PMID: 1675916 DOI: 10.1016/0006-8993(91)90521-v

Abstract

The effect of the alpha 2 antagonist, idazoxan (IDA), on the excitability of neurons in the dentate gyrus of the hippocampus was studied. Population field potentials (PS) evoked by stimulation of the perforant pathway were measured before and after drug treatment. IDA enhanced the amplitude of the PS, while decreasing the slope of the EPSP. Neurotoxic destruction of noradrenergic nerve terminals completely abolished the IDA effect, arguing that its mechanism of action is through enhanced release of noradrenaline (NA). It is proposed that NA enhances the EPSP-to-spike coupling component of the PS.

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