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Bianchi G. Antidiuretic effect of bremazocine and U-50,488 in rats after alpha 2-adrenoceptor blockade. J Pharm Pharmacol. 1991;43(3):212-6doi: 10.1111/j.2042-7158.1991.tb06670.x.
Bianchi, G. (1991). Antidiuretic effect of bremazocine and U-50,488 in rats after alpha 2-adrenoceptor blockade. The Journal of pharmacy and pharmacology, 43(3), 212-6. https://doi.org/10.1111/j.2042-7158.1991.tb06670.x
Bianchi, G. "Antidiuretic effect of bremazocine and U-50,488 in rats after alpha 2-adrenoceptor blockade." The Journal of pharmacy and pharmacology vol. 43,3 (1991): 212-6. doi: https://doi.org/10.1111/j.2042-7158.1991.tb06670.x
Bianchi G. Antidiuretic effect of bremazocine and U-50,488 in rats after alpha 2-adrenoceptor blockade. J Pharm Pharmacol. 1991 Mar;43(3):212-6. doi: 10.1111/j.2042-7158.1991.tb06670.x. PMID: 1675283.
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J Pharm Pharmacol. 1991 Mar;43(3):212-6. doi: 10.1111/j.2042-7158.1991.tb06670.x.

Antidiuretic effect of bremazocine and U-50,488 in rats after alpha 2-adrenoceptor blockade.

The Journal of pharmacy and pharmacology

G Bianchi

Affiliations

  1. Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.

PMID: 1675283 DOI: 10.1111/j.2042-7158.1991.tb06670.x

Abstract

The role of alpha 2-adrenoceptors and kappa-opioid receptors in urination was studied in rats. In water-loaded rats (40 mL kg-1 p.o.) the kappa-opioid agonist bremazocine (0.05 0.2 mg kg-1 i.p.) induced a dose-related diuretic response in the second hour after administration, but had no effect in the first hour. When rats were pretreated with the alpha 2-adrenoceptor antagonist idazoxan (1 mg kg-1 s.c.), bremazocine induced a dose-related antidiuretic response in the first hour; thereafter the rats showed an increase of urination similar to that with bremazocine alone. The antidiuretic effect of bremazocine was dependent on the dose of idazoxan with maximal response after 1-3 mg kg-1. Similar results were obtained with bremazocine in the presence of yohimbine (1 mg kg-1 s.c.). The antidiuretic profile of bremazocine after idazoxan was shared by U-50,488 (2.5-10 mg kg-1 i.p.), although this compound alone at the high dose reduces urine output in the first hour. The antidiuresis induced by bremazocine in the presence of idazoxan in water-loaded rats was completely antagonized by 10 but not 2 mg kg-1 i.p. of the opioid antagonist naloxone. Thus, kappa-opioid agonists, in addition to their diuretic effect, also produce an antidiuretic response which may be mediated by alpha 2-adrenoceptors.

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