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Neurologist. 2005 Mar;11(2):63-79. doi: 10.1097/01.nrl.0000156314.24508.ed.

Diabetic neuropathies. Classification, clinical features, and pathophysiological basis.

The neurologist

Michael Sinnreich, Bruce V Taylor, P James B Dyck

Affiliations

  1. Department of Neurology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA.

PMID: 15733329 DOI: 10.1097/01.nrl.0000156314.24508.ed

Abstract

Diabetes mellitus is associated with a wide spectrum of neuropathy syndromes, ranging from a mild asymptomatic distal sensory neuropathy to a severe disabling radiculoplexus neuropathy. As the pathophysiology of these separate conditions is better understood, classification of the various phenotypes becomes important because of treatment implications. Here we provide a short summary of the history of the classification of diabetic neuropathies and try to describe the most common forms classified according to their presumed pathophysiology. We have tried to include epidemiological data where available, as well as histopathology of nerve in several diabetic neuropathies.

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