Display options
Cite
Berthezène Y, Vexler V, Clément O, et al. Contrast-enhanced MR imaging of the lung: assessments of ventilation and perfusion. Radiology. 1992;183(3):667-72doi: 10.1148/radiology.183.3.1584916.
Berthezène, Y., Vexler, V., Clément, O., Mühler, A., Moseley, M. E., & Brasch, R. C. (1992). Contrast-enhanced MR imaging of the lung: assessments of ventilation and perfusion. Radiology, 183(3), 667-72. https://doi.org/10.1148/radiology.183.3.1584916
Berthezène, Y, et al. "Contrast-enhanced MR imaging of the lung: assessments of ventilation and perfusion." Radiology vol. 183,3 (1992): 667-72. doi: https://doi.org/10.1148/radiology.183.3.1584916
Berthezène Y, Vexler V, Clément O, Mühler A, Moseley ME, Brasch RC. Contrast-enhanced MR imaging of the lung: assessments of ventilation and perfusion. Radiology. 1992 Jun;183(3):667-72. doi: 10.1148/radiology.183.3.1584916. PMID: 1584916.
Copy Download .nbib Format: NLM
Share it on
Full text links
Atypon

Radiology. 1992 Jun;183(3):667-72. doi: 10.1148/radiology.183.3.1584916.

Contrast-enhanced MR imaging of the lung: assessments of ventilation and perfusion.

Radiology

Y Berthezène, V Vexler, O Clément, A Mühler, M E Moseley, R C Brasch

Affiliations

  1. Department of Radiology, University of California, San Francisco 94143-0628.

PMID: 1584916 DOI: 10.1148/radiology.183.3.1584916

Abstract

The use of aerosolized gadopentetate dimeglumine to define regional lung ventilation and of intravenously administered polylysine-(gadopentetate dimeglumine)40 to assess regional lung perfusion was investigated. In 10 healthy rats who breathed aerosolized gadopentetate dimeglumine (0.25 mol/L) for 5 minutes, pulmonary signal intensity increased diffusely in both lungs by more than 70%. When the same animals received intravenously administered polylysine-(gadopentetate dimeglumine)40 (0.1 mmol of gadolinium per kilogram), there was an additional 300% enhancement of the pulmonary parenchyma. In a rat model of acute unilateral pulmonary embolism (n = 5), perfusion defects were identified after administration of polylysine-(gadopentetate dimeglumine)40, but no ventilation abnormality was seen after inhalation of gadopentetate dimeglumine. In a rat model of acute unilateral airway obstruction (n = 5), only the ventilated right lung enhanced after inhalation of gadopentetate dimeglumine. In four of these animals, the focal ventilation defect was accompanied by a matched decrease in perfusion, seen after enhancement of the blood pool with polylysine-(gadopentetate dimeglumine)40.

Cited by

Substances

MeSH terms

Publication Types

Grant support

LinkOut - more resources