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McMillan CO, Spahr-Schopfer IA, Sikich N, et al. Premedication of children with oral midazolam. Can J Anaesth. 1992;39(6):545-50doi: 10.1007/BF03008315.
McMillan, C. O., Spahr-Schopfer, I. A., Sikich, N., Hartley, E., & Lerman, J. (1992). Premedication of children with oral midazolam. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 39(6), 545-50. https://doi.org/10.1007/BF03008315
McMillan, C O, et al. "Premedication of children with oral midazolam." Canadian journal of anaesthesia = Journal canadien d'anesthesie vol. 39,6 (1992): 545-50. doi: https://doi.org/10.1007/BF03008315
McMillan CO, Spahr-Schopfer IA, Sikich N, Hartley E, Lerman J. Premedication of children with oral midazolam. Can J Anaesth. 1992 Jul;39(6):545-50. doi: 10.1007/BF03008315. PMID: 1643676.
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Can J Anaesth. 1992 Jul;39(6):545-50. doi: 10.1007/BF03008315.

Premedication of children with oral midazolam.

Canadian journal of anaesthesia = Journal canadien d'anesthesie

C O McMillan, I A Spahr-Schopfer, N Sikich, E Hartley, J Lerman

Affiliations

  1. Department of Anaesthesia, Hospital for Sick Children, University of Toronto, Ontario, Canada.

PMID: 1643676 DOI: 10.1007/BF03008315

Abstract

In a randomized, double-blind, placebo-controlled study, the safety, efficacy and feasibility of oral midazolam premedication in children were evaluated in an ambulatory surgery unit. Eighty unmedicated children (ASA PS I or II, ages 1-6 yr) were randomly assigned to one of four groups receiving midazolam 0.5, 0.75, or 1.0 mg.kg-1 or a placebo 30 min before separation from parents. Heart rate, systolic blood pressure, arterial oxygen saturation, respiratory rate, sedation and anxiolysis scores were recorded before premedication, every five minutes for 30 min and then during induction of anaesthesia and recovery. We found that heart rate, systolic blood pressure, arterial oxygen saturation and respiratory rate were unchanged during the study. Sedation and anxiolysis scores in the midazolam-treated groups were greater than those in the placebo group and that anxiolysis at the time of separation from the parents was judged excellent in 80-90% of the children who received midazolam. However, sedation and anxiolysis did not differ among the three midazolam groups. Mean times to discharge from hospital were similar for all four groups. The side effects, loss of balance and head control, blurred vision and dysphoric reactions were observed only in the 0.75 and 1.0 mg.kg-1 midazolam groups. We conclude that oral midazolam 0.5 mg.kg-1 is a safe and effective premedication and that 0.75 and 1 mg.kg-1 while offering no additional benefit, may cause more side effects.

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