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Smart CJ, Heatley RV, Trejdosiewicz LK. Expression of CD6 and the UCHL1-defined CD45 (p180) antigen by human colonic T lymphocytes. Immunology. 1989;66(1):90-5
Smart, C. J., Heatley, R. V., & Trejdosiewicz, L. K. (1989). Expression of CD6 and the UCHL1-defined CD45 (p180) antigen by human colonic T lymphocytes. Immunology, 66(1), 90-5.
Smart, C J, et al. "Expression of CD6 and the UCHL1-defined CD45 (p180) antigen by human colonic T lymphocytes." Immunology vol. 66,1 (1989): 90-5.
Smart CJ, Heatley RV, Trejdosiewicz LK. Expression of CD6 and the UCHL1-defined CD45 (p180) antigen by human colonic T lymphocytes. Immunology. 1989 Jan;66(1):90-5. PMID: 15493268; PMCID: PMC1385125.
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Immunology. 1989 Jan;66(1):90-5.

Expression of CD6 and the UCHL1-defined CD45 (p180) antigen by human colonic T lymphocytes.

Immunology

C J Smart, R V Heatley, L K Trejdosiewicz

Affiliations

  1. Department of Medicine, University of Leeds, St James' Hospital, Leeds, UK.

PMID: 15493268 PMCID: PMC1385125

Abstract

Cryostat sections of histologically normal human colon were studied by double-label immunofluorescence techniques using a panel of monoclonal antibodies to T-lineage antigens and activation markers, with particular reference to the CD6 antigen. In the lamina propria, the majority population of T cells was of the CD3+, CD6+, CD4+ subset, of which virtually all were of the UCHL1+, CD45R-, Leu 8- phenotype of antigen-committed helper T cells. This majority lamina propria population did not express markers associated with blastogenesis (CD7), activation (MHC class II, CD25, CD38) or proliferation (OKT9, Ki67). In both intra-epithelial and lamina propria compartments, a subpopulation of CD3+ T cells was identified which did not express either the CD6 or CD5 peripheral 'pan T' markers. Most of the CD3+, CD6- cells were of the CD8+ (cytotoxic-suppressor) subset which co-expressed the CD7 antigen with a much higher frequency than did the CD6+ subpopulation. Expression of CD25, CD38 and HLA-D antigens, although infrequent, was confined to this CD8+, CD5-, CD6- population. Our data thus imply that the colonic mucosa is largely populated by mature, antigen-committed resting T cells of the helper-inducer phenotype.

References

  1. Gut. 1981 Mar;22(3):169-76 - PubMed
  2. J Immunol. 1988 Apr 1;140(7):2171-8 - PubMed
  3. Clin Exp Immunol. 1981 Dec;46(3):597-606 - PubMed
  4. J Immunol. 1982 Nov;129(5):1997-2000 - PubMed
  5. Clin Haematol. 1982 Oct;11(3):631-60 - PubMed
  6. J Immunol. 1983 Jun;130(6):2615-22 - PubMed
  7. Blood. 1983 Nov;62(5):1108-13 - PubMed
  8. Clin Exp Immunol. 1984 Feb;55(2):427-36 - PubMed
  9. J Immunol. 1984 Aug;133(2):724-8 - PubMed
  10. J Immunol. 1985 May;134(5):2995-3002 - PubMed
  11. Clin Exp Immunol. 1985 May;60(2):437-46 - PubMed
  12. Scand J Gastroenterol Suppl. 1985;114:1-15 - PubMed
  13. Dig Dis Sci. 1986 Jun;31(6):593-603 - PubMed
  14. J Immunol. 1986 Sep 15;137(6):1816-21 - PubMed
  15. J Clin Immunol. 1987 Jul;7(4):265-76 - PubMed
  16. J Exp Med. 1987 Nov 1;166(5):1471-83 - PubMed
  17. Adv Exp Med Biol. 1987;216A:465-73 - PubMed
  18. Proc Natl Acad Sci U S A. 1981 Jul;78(7):4515-9 - PubMed

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