Display options
Cite
Williams JD, Maskell JP, Shain H, et al. Comparative in-vitro activity of azithromycin, macrolides (erythromycin, clarithromycin and spiramycin) and streptogramin RP 59500 against oral organisms. J Antimicrob Chemother. 1992;30(1):27-37doi: 10.1093/jac/30.1.27.
Williams, J. D., Maskell, J. P., Shain, H., Chrysos, G., Sefton, A. M., Fraser, H. Y., & Hardie, J. M. (1992). Comparative in-vitro activity of azithromycin, macrolides (erythromycin, clarithromycin and spiramycin) and streptogramin RP 59500 against oral organisms. The Journal of antimicrobial chemotherapy, 30(1), 27-37. https://doi.org/10.1093/jac/30.1.27
Williams, J D, et al. "Comparative in-vitro activity of azithromycin, macrolides (erythromycin, clarithromycin and spiramycin) and streptogramin RP 59500 against oral organisms." The Journal of antimicrobial chemotherapy vol. 30,1 (1992): 27-37. doi: https://doi.org/10.1093/jac/30.1.27
Williams JD, Maskell JP, Shain H, Chrysos G, Sefton AM, Fraser HY, Hardie JM. Comparative in-vitro activity of azithromycin, macrolides (erythromycin, clarithromycin and spiramycin) and streptogramin RP 59500 against oral organisms. J Antimicrob Chemother. 1992 Jul;30(1):27-37. doi: 10.1093/jac/30.1.27. PMID: 1331019.
Copy Download .nbib Format: NLM
Share it on
Full text links
Silverchair Information Systems

J Antimicrob Chemother. 1992 Jul;30(1):27-37. doi: 10.1093/jac/30.1.27.

Comparative in-vitro activity of azithromycin, macrolides (erythromycin, clarithromycin and spiramycin) and streptogramin RP 59500 against oral organisms.

The Journal of antimicrobial chemotherapy

J D Williams, J P Maskell, H Shain, G Chrysos, A M Sefton, H Y Fraser, J M Hardie

Affiliations

  1. Department of Medical Microbiology, London Hospital Medical College, UK.

PMID: 1331019 DOI: 10.1093/jac/30.1.27

Abstract

The in-vitro activities of azithromycin, clarithromycin, spiramycin and RP 59500 were compared with erythromycin against a wide range of oral organisms which have been implicated in oral infections and/or endocarditis (clindamycin was included for oral streptococci). All compounds tested showed good activity against many of these organisms, although some variation was observed with different species. Clarithromycin was the most active of the antibiotics tested against Gram-positive anaerobes, including Actinomyces spp., Propionibacterium spp., Lactobacillus spp. and Bifidobacterium dentium. Azithromycin was slightly less active than erythromycin against these species. In general, RP 59500 had higher MICs than the macrolides, other than spiramycin, against these organisms, but was superior in activity against Peptostreptococcus spp., inhibiting all isolates at 2 mg/L. Azithromycin was, in general, the most active antibiotic tested against the Gram-negative anaerobes: Fusobacterium spp., Bacteroides spp., Wolinella spp., Actinobacillus actinomycetemcomitans, Selenomonas spp. and Mitsuokella multiacida, including those isolates which were insusceptible to erythromycin. Clarithromycin showed similar activity to erythromycin against most Gram-negative species, but was superior against Capnocytophaga ochraceus and Eikenella corrodens. RP 59500 was less active than the macrolides against most Gram-negative anaerobes, but was superior to erythromycin and clarithromycin against Fusobacterium spp. and Leptotrichia buccalis, some strains of which were moderately resistant to erythromycin. The macrolides and clindamycin were about equally active against the oral streptococci, whereas RP 59500 showed lower inhibitory activity. The in-vitro results suggest that azithromycin and clarithromycin may be of value in the treatment of dental sepsis and the prophylaxis of endocarditis. RP 59500 showed useful activity against Gram-positive anaerobes and, because of its bactericidal activity against oral streptococci, may also prove to have a role in these areas.

Similar articles

Maier L, Goemans CV, Wirbel J, Kuhn M, Eberl C, Pruteanu M, Müller P, Garcia-Santamarina S, Cacace E, Zhang B, Gekeler C, Banerjee T, Anderson EE, Milanese A, Löber U, Forslund SK, Patil KR, Zimmermann M, Stecher B, Zeller G, Bork P, Typas A.
Nature. 2021 Nov;599(7883):120-124. doi: 10.1038/s41586-021-03986-2. Epub 2021 Oct 13.
PMID: 34646011

Noli C, Boothe D.
Vet Dermatol. 1999 Sep;10(3):217-223. doi: 10.1046/j.1365-3164.1999.00176.x.
PMID: 34644913

McCarty JM.
Infect Dis Obstet Gynecol. 1996;4(4):215-20. doi: 10.1155/S1064744996000415.
PMID: 18476095

Show all 18 similar articles

Cited by

Substances

MeSH terms

Publication Types

LinkOut - more resources