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Kaloutsi V, Hadjileontis C, Tsatalas C, et al. Occurrence of a variant Philadelphia translocation, t(10;22), in de novo acute megakaryoblastic leukemia. Cancer Genet Cytogenet. 2004;152(1):52-5doi: 10.1016/j.cancergencyto.2003.08.022.
Kaloutsi, V., Hadjileontis, C., Tsatalas, C., Sambani, C., Kostopoulos, I., & Papadimitriou, C. (2004). Occurrence of a variant Philadelphia translocation, t(10;22), in de novo acute megakaryoblastic leukemia. Cancer genetics and cytogenetics, 152(1), 52-5. https://doi.org/10.1016/j.cancergencyto.2003.08.022
Kaloutsi, Vassiliki, et al. "Occurrence of a variant Philadelphia translocation, t(10;22), in de novo acute megakaryoblastic leukemia." Cancer genetics and cytogenetics vol. 152,1 (2004): 52-5. doi: https://doi.org/10.1016/j.cancergencyto.2003.08.022
Kaloutsi V, Hadjileontis C, Tsatalas C, Sambani C, Kostopoulos I, Papadimitriou C. Occurrence of a variant Philadelphia translocation, t(10;22), in de novo acute megakaryoblastic leukemia. Cancer Genet Cytogenet. 2004 Jul 01;152(1):52-5. doi: 10.1016/j.cancergencyto.2003.08.022. PMID: 15193441.
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Cancer Genet Cytogenet. 2004 Jul 01;152(1):52-5. doi: 10.1016/j.cancergencyto.2003.08.022.

Occurrence of a variant Philadelphia translocation, t(10;22), in de novo acute megakaryoblastic leukemia.

Cancer genetics and cytogenetics

Vassiliki Kaloutsi, Constantine Hadjileontis, Constantine Tsatalas, Constantina Sambani, Ioannis Kostopoulos, Constantine Papadimitriou

Affiliations

  1. Department of Pathology, Medical School, Aristotle University of Thessaloniki, 54006, Thessaloniki, Greece. [email protected]

PMID: 15193441 DOI: 10.1016/j.cancergencyto.2003.08.022

Abstract

Acute megakaryoblastic leukemia (AMegL) in adults is a very rare subtype of acute myeloid leukemia (AML) and is characterized by a larger diversity of chromosomal abnormalities than the other subtypes, including 3q21q26 changes, aberrations of chromosomes 5 and 7, and the t(9;22)(q34;q11). We report the case of a 24-year-old patient with de novo AMegL and thrombocythemic cell count. Diagnosis was established with a bone marrow biopsy, and cytogenetics with G-banding revealed a t(10;22), which by FISH, was found to be a variant Philadelphia translocation involving chromosome 10q in all 20 metaphases analyzed. We believe that this is the first report of de novo AMegL with this chromosomal abnormality, and its possible correlation with morphology and thrombocytosis is discussed.

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