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Chinese Medical Association Publishing House Ltd.

Zhonghua Yi Xue Za Zhi. 1992 May;72(5):265-8, 318.

[The effects of early stage load-bearing on bone ingrowth of porous coated implant in rabbits].

Zhonghua yi xue za zhi

[Article in Chinese]
Y Sun

Affiliations

  1. Department of Orthopeadics, General Hospital, PLA, Beijing.

PMID: 1327457

Abstract

To understand the effects of load-bearing on cementless fixation of porous coated implant, we inserted Co-Cr-Mo alloy implants into the distal femur of rabbits. Specimens were studied by means of histology, anti-collagen type I and III immunohistochemical staining, colloidal gold labeled immunoelectron microscopy, and computerized graphic analysis. The results revealed that stimulations of load-bearing benefited bone ingrowth, but the newly formed bone in the pores was absorbed and replaced by fibrous tissues after 12 weeks without stimulations of load-bearing. The fibrous tissues in the pores of the implant were primarily type III collagen after one week and type I collagen after two weeks. After 6 weeks, the residual tissue between ingrowth bone and metal bound antibodies was type I collagen. Fibroblasts participated in and possessed the action of osteogenesis.

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