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Alshuaib WB, Mathew MV. Inhibition of transient K+ current by copper in Drosophila neurons. Neurochem Res. 2004;29(4):785-9doi: 10.1023/b:nere.0000018851.62617.36.
Alshuaib, W. B., & Mathew, M. V. (2004). Inhibition of transient K+ current by copper in Drosophila neurons. Neurochemical research, 29(4), 785-9. https://doi.org/10.1023/b:nere.0000018851.62617.36
Alshuaib, Waleed B, and Mathew, Mini V. "Inhibition of transient K+ current by copper in Drosophila neurons." Neurochemical research vol. 29,4 (2004): 785-9. doi: https://doi.org/10.1023/b:nere.0000018851.62617.36
Alshuaib WB, Mathew MV. Inhibition of transient K+ current by copper in Drosophila neurons. Neurochem Res. 2004 Apr;29(4):785-9. doi: 10.1023/b:nere.0000018851.62617.36. PMID: 15098942.
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Neurochem Res. 2004 Apr;29(4):785-9. doi: 10.1023/b:nere.0000018851.62617.36.

Inhibition of transient K+ current by copper in Drosophila neurons.

Neurochemical research

Waleed B Alshuaib, Mini V Mathew

Affiliations

  1. Department of Physiology, Faculty of Medicine, Kuwait University, Safat. [email protected]

PMID: 15098942 DOI: 10.1023/b:nere.0000018851.62617.36

Abstract

The transient K+ current (IK(A)) affects the rate of repetitive action potentials. The whole-cell patch-clamp technique was applied to cultured Drosophila neurons derived from embryonic neuroblasts. IK(A) was measured from neurons before and after application of 0.1 mM copper to the external saline. IK(A) was smaller in the copper-containing saline (12.0 +/- 1.6 pA) than in the control saline (37 +/- 6.5 pA). Activation and inactivation of IK(A) were unchanged by copper. These results suggest that copper can influence neuronal excitability and may affect neuronal function.

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