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Matuo Y, McKeehan WL, Yan GC, et al. Potential role of HBGF (FGF) and TGF-beta on prostate growth. Adv Exp Med Biol. 1992;324:107-14doi: 10.1007/978-1-4615-3398-6_11.
Matuo, Y., McKeehan, W. L., Yan, G. C., Nikolaropoulos, S., Adams, P. S., Fukabori, Y., Yamanaka, H., & Gaudreau, J. (1992). Potential role of HBGF (FGF) and TGF-beta on prostate growth. Advances in experimental medicine and biology, 324107-14. https://doi.org/10.1007/978-1-4615-3398-6_11
Matuo, Y, et al. "Potential role of HBGF (FGF) and TGF-beta on prostate growth." Advances in experimental medicine and biology vol. 324 (1992): 107-14. doi: https://doi.org/10.1007/978-1-4615-3398-6_11
Matuo Y, McKeehan WL, Yan GC, Nikolaropoulos S, Adams PS, Fukabori Y, Yamanaka H, Gaudreau J. Potential role of HBGF (FGF) and TGF-beta on prostate growth. Adv Exp Med Biol. 1992;324:107-14. doi: 10.1007/978-1-4615-3398-6_11. PMID: 1492611.
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Adv Exp Med Biol. 1992;324:107-14. doi: 10.1007/978-1-4615-3398-6_11.

Potential role of HBGF (FGF) and TGF-beta on prostate growth.

Advances in experimental medicine and biology

Y Matuo, W L McKeehan, G C Yan, S Nikolaropoulos, P S Adams, Y Fukabori, H Yamanaka, J Gaudreau

Affiliations

  1. W. Alton Jones Cell Science Center, Lake Placid, NY 12946.

PMID: 1492611 DOI: 10.1007/978-1-4615-3398-6_11

Abstract

We review in this paper the role of heparin-binding growth factor (HBGF*) or fibroblast growth factor (FGF*), rat prostate cancer cells produce TGF-beta, IGF-II* and OGF*. Of these growth factors, TGF-beta and unknown labile factor with 19 kDa are the most probable candidates responsible for osteoblastic bony metastasis of prostate cancer. In vitro experiments suggest that TGF-beta modulates cell detachment of prostate cancer cells together with nutritional factors. HBGF-dependent growth of the prostate tumor epithelial cells is free from inhibition by TGF-beta, whereas normal prostate epithelial cells are sensitive to TGF-beta inhibition. Transfection experiments suggest that HBGF-2 (basic FGF) might be closely related to the malignant growth of prostate cancer, in addition to tumor angiogenesis.

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