Int J Cancer. 1979 Oct 15;24(4):385-93. doi: 10.1002/ijc.2910240402.

Light chain isotype-associated suppression of normal plasma cell numbers in patients with multiple myeloma: Medical Research Council's Working Party for Leukaemia in Adults and the Oxford Lymphoma Group.

International journal of cancer

R C Leonard, I C MacLennan, Y Smart, R I Vanhegan, J Cuzick

PMID: 118938 DOI: 10.1002/ijc.2910240402

Abstract

The number of plasma cells in the lamina propria of the gut has been assessed in patients with multiple myeloma and other B-cell neoplasms. The total number of these plasma cells was reduced in most patients with myelomatosis and one-third of patients with lymphoplasmacytoid tumours. This reduction was not, however, seen in patients with other neoplasms of B-cell origin, although hypogammaglobulinaemia was common to all groups of patients. The depletion of gut plasma cell numbers was not uniform in myelomatosis patients. They showed selective loss of plasma cells with the same light chain isotype as that produced by the neoplastic clone.

Substances

• Immunoglobulin A
• Immunoglobulin G
• Immunoglobulin Light Chains
• Immunoglobulin M
• Immunoglobulin kappa-Chains
• Immunoglobulin lambda-Chains
• Immunoglobulins
• Paraproteins

MeSH terms

• Cell Count
• Humans
• Immunoglobulin A / analysis
• Immunoglobulin G / analysis
• Immunoglobulin Light Chains / analysis
• Immunoglobulin M / analysis
• Immunoglobulin kappa-Chains / analysis
• Immunoglobulin lambda-Chains / analysis
• Immunoglobulins / analysis
• Intestinal Mucosa / pathology
• Lymphoma / immunology
• Lymphoma / pathology
• Multiple Myeloma / immunology
• Multiple Myeloma / pathology
• Paraproteins / analysis
• Plasma Cells / immunology
• Rectum / pathology

Publication Types

• Journal Article

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