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Ohtsu Y, Sasamura H, Tsurumi Y, et al. The novel gluconeogenesis inhibitors FR225659 and related compounds that originate from Helicomyces sp. No. 19353. I. Taxonomy, fermentation, isolation and physico-chemical properties. J Antibiot (Tokyo). 2003;56(8):682-8doi: 10.7164/antibiotics.56.682.
Ohtsu, Y., Sasamura, H., Tsurumi, Y., Yoshimura, S., Takase, S., Hashimoto, M., Shibata, T., Hino, M., & Fujii, T. (2003). The novel gluconeogenesis inhibitors FR225659 and related compounds that originate from Helicomyces sp. No. 19353. I. Taxonomy, fermentation, isolation and physico-chemical properties. The Journal of antibiotics, 56(8), 682-8. https://doi.org/10.7164/antibiotics.56.682
Ohtsu, Yoshihiro, et al. "The novel gluconeogenesis inhibitors FR225659 and related compounds that originate from Helicomyces sp. No. 19353. I. Taxonomy, fermentation, isolation and physico-chemical properties." The Journal of antibiotics vol. 56,8 (2003): 682-8. doi: https://doi.org/10.7164/antibiotics.56.682
Ohtsu Y, Sasamura H, Tsurumi Y, Yoshimura S, Takase S, Hashimoto M, Shibata T, Hino M, Fujii T. The novel gluconeogenesis inhibitors FR225659 and related compounds that originate from Helicomyces sp. No. 19353. I. Taxonomy, fermentation, isolation and physico-chemical properties. J Antibiot (Tokyo). 2003 Aug;56(8):682-8. doi: 10.7164/antibiotics.56.682. PMID: 14563156.
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J Antibiot (Tokyo). 2003 Aug;56(8):682-8. doi: 10.7164/antibiotics.56.682.

The novel gluconeogenesis inhibitors FR225659 and related compounds that originate from Helicomyces sp. No. 19353. I. Taxonomy, fermentation, isolation and physico-chemical properties.

The Journal of antibiotics

Yoshihiro Ohtsu, Hiromi Sasamura, Yasuhisa Tsurumi, Seiji Yoshimura, Shigehiro Takase, Michizane Hashimoto, Toshihiro Shibata, Motohiro Hino, Takashi Fujii

Affiliations

  1. Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 5-2-3 Tokodai, Tsukuba, Ibaraki 300-2698, Japan. [email protected]

PMID: 14563156 DOI: 10.7164/antibiotics.56.682

Abstract

FR225659 and four related compounds are novel gluconeogenesis inhibitors that consist of a novel acyl-group and three abnormal amino acids. They were isolated from the culture broth of Helicomyces sp. No. 19353 and can be purified by absorptive resin and reverse-phase column chromatography. They are potent inhibitors of gluconeogenesis in primary cultured rat hepatocytes and thus may be useful as anti-diabetic agents.

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