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Brack T, Scholz RB, Milde-Langosch K, et al. Detection of N-myc gene amplification in bone marrow specimen of stage IV neuroblastoma patients. Cancer Detect Prev. 1992;16(3):185-92
Brack, T., Scholz, R. B., Milde-Langosch, K., Heinsohn, S., Löning, T., & Kabisch, H. (1992). Detection of N-myc gene amplification in bone marrow specimen of stage IV neuroblastoma patients. Cancer detection and prevention, 16(3), 185-92.
Brack, T, et al. "Detection of N-myc gene amplification in bone marrow specimen of stage IV neuroblastoma patients." Cancer detection and prevention vol. 16,3 (1992): 185-92.
Brack T, Scholz RB, Milde-Langosch K, Heinsohn S, Löning T, Kabisch H. Detection of N-myc gene amplification in bone marrow specimen of stage IV neuroblastoma patients. Cancer Detect Prev. 1992;16(3):185-92. PMID: 1458508.
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Cancer Detect Prev. 1992;16(3):185-92.

Detection of N-myc gene amplification in bone marrow specimen of stage IV neuroblastoma patients.

Cancer detection and prevention

T Brack, R B Scholz, K Milde-Langosch, S Heinsohn, T Löning, H Kabisch

Affiliations

  1. Children's Hospital, Department of Hematology and Oncology, Hamburg, Germany.

PMID: 1458508

Abstract

N-myc gene amplification is an unfavorable prognostic factor in neuroblastoma; therefore, its detection might have therapeutical consequences. Because of the reliability of noninvasive diagnostic methods such as X-ray examination and measurement of vanilymandelic acid and the lack of technical unavailability at most institutions, the determination of the N-myc status of neuroblastoma often is not done. In our investigation of 14 neuroblastoma patients, we could demonstrate N-myc gene amplification in the bone marrow of 5 patients with neuroblastoma stage IV disease and in bone marrow infiltration without enrichment of neuroblastoma cells. Otherwise, no information about the tumor content of N-myc gene copies at the time of initial diagnosis could be obtained. At the subsequent resection, the N-myc gene amplification was confirmed by the additional Southern blot analysis and in situ hybridization of tumor tissue. Furthermore, the N-myc status of bone marrow was analyzed during the stages of chemotherapy in three cases.

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